Clinical Outcomes of Patients Treated for Candida auris Infections in a Multisite Health System, Illinois, USA

被引：40

作者：

Arensman, Kellie ^{[1
]}

Miller, Jessica L. ^{[2
,3
]}

Chiang, Anthony ^{[4
]}

Mai, Nathan ^{[5
]}

Levato, Joseph ^{[5
]}

LaChance, Erik ^{[6
]}

Anderson, Morgan ^{[7
,8
]}

Beganovic, Maya ^{[1
]}

Dela Pena, Jennifer ^{[1
]}

机构：

[1] Advocate Lutheran Gen Hosp, 1775 Dempster St, Park Ridge, IL 60068 USA

[2] Advocate South Suburban Hosp, Hazel Crest, IL USA

[3] Advocate Trinity Hosp, Chicago, IL USA

[4] Swedish Covenant Hosp, Chicago, IL USA

[5] Advocate Christ Med Ctr, Oak Lawn, IL USA

[6] Advocate Illinois Masonic Med Ctr, Chicago, IL USA

[7] Advocate Condell Med Ctr, Libertyville, IL USA

[8] Advocate Good Shepherd Hosp, Barrington, IL USA

来源：

EMERGING INFECTIOUS DISEASES | 2020年 / 26卷 / 05期

关键词：

CARE FACILITIES; UNITED-STATES; NEW-YORK; MANAGEMENT; EMERGENCE; FUNGEMIA;

D O I：

10.3201/eid2605.191588

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Candida auris is an emerging fungal pathogen that is typically resistant to fluconazole and is known to cause healthcare-associated outbreaks. We retrospectively reviewed 28 patients who had >1 positive culture for C. auris within a multisite health system in Illinois, USA, during May 2018-April 2019. Twelve of these patients were treated as inpatients for C. auris infections; 10 (83%) met criteria for clinical success, defined as absence of all-cause mortality, C. auris recurrence, and infection-related readmission at 30 days from the first positive culture. The other 2 patients (17%) died within 30 days. Most patients (92%) were empirically treated with micafungin. Four (14%) of 28 total isolates were resistant to fluconazole, 1 (3.6%) was resistant to amphotericin B, and 1 (3.6%) was resistant to echinocandins. Our findings describe low rates of antifungal resistance and favorable clinical outcomes for most C. auris patients.

引用

页码：866 / 871

页数：6

共 22 条

[21] Ongoing Transmission of Candida auris in Health Care Facilities - United States, June 2016-May 2017 [J].

Tsay, Sharon ;

Welsh, Rory M. ;

Adams, Eleanor H. ;

Chow, Nancy A. ;

Gade, Lalitha ;

Berkow, Elizabeth L. ;

Poirot, Eugenie ;

Lutterloh, Emily ;

Quinn, Monica ;

Chaturvedi, Sudha ;

Kerins, Janna ;

Black, Stephanie R. ;

Kemble, Sarah K. ;

Barrett, Patricia M. ;

Barton, Kerri ;

Shannon, D. J. ;

Bradley, Kristy ;

Lockhart, Shawn R. ;

Litvintseva, Anastasia P. ;

Moulton-Meissner, Heather ;

Shugart, Alicia ;

Kallen, Alex ;

Vallabhaneni, Snigdha ;

Chiller, Tom M. ;

Jackson, Brendan R. .

MMWR-MORBIDITY AND MORTALITY WEEKLY REPORT, 2017, 66 (19) :514-+

[22]

Vallabhaneni S, 2016, MMWR-MORBID MORTAL W, V65, P1234, DOI [10.15585/mmwr.mm6544e1, 10.1111/ajt.14121]

← 1 2 3 →