Chemotherapy-induced cognitive impairments: White matter pathologies

被引：23
作者：
Matsos, A. [1 ]
Loomes, M. [1 ]
Zhou, I. [1 ]
Macmillan, E. [1 ]
Sabel, I. [1 ]
Rotziokos, E. [1 ]
Beckwith, W. [1 ]
Johnston, I. N. [1 ]
机构：
[1] Univ Sydney, Sch Psychol, Sydney, NSW 2006, Australia
来源：
CANCER TREATMENT REVIEWS | 2017年 / 61卷
关键词：
Cancer; Chemotherapy; White matter; Myelin; Corpus callosum and processing speed; CENTRAL-NERVOUS-SYSTEM; ACUTE LYMPHOBLASTIC-LEUKEMIA; BREAST-CANCER SURVIVORS; DEFAULT MODE NETWORK; PRIMARY CNS LYMPHOMA; LONG-TERM SURVIVORS; OXIDATIVE STRESS; MITOCHONDRIAL DYSFUNCTION; FUNCTIONAL CONNECTIVITY; LONGITUDINAL ASSESSMENT;
D O I：
10.1016/j.ctrv.2017.09.010
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Whilst chemotherapeutic agents show promising results in the amelioration of cancerous tumors, patients often experience cognitive disturbances associated with chemotherapy long after treatment has ceased. Research has suggested that the structural integrity of white matter fibres in the brain are susceptible to the harmful effects of chemotherapy. Post-chemotherapy, white matter tracts often display altered morphology with a reduction in glial cells such as oligodendrocytes. Demyelination, gliosis and leukoencephalopathy during or post chemotherapy is associated with changes in processing speed and IQ, Thus, understanding the relationship between chemotherapy, white matter damage and cognition is warranted. This review presents evidence for chemotherapy induced white matter damage highlighting the importance of implementing behavioral and pharmological strategies to prevent or reverse such acute toxicity in the brain. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：6 / 14
页数：9
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