Platelet-Rich Plasma Derived Growth Factors Contribute to Stem Cell Differentiation in Musculoskeletal Regeneration

被引：100
|
作者：
Qian, Yun [1 ,2 ]
Han, Qixin [3 ]
Chen, Wei [1 ,2 ]
Song, Jialin [1 ,2 ]
Zhao, Xiaotian [4 ]
Ouyang, Yuanming [1 ,2 ]
Yuan, Weien [4 ]
Fan, Cunyi [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Dept Orthoped, Affiliated Peoples Hosp 6, Shanghai, Peoples R China
[2] Shanghai Univ Med & Hlth, Shanghai Sixth Peoples Hosp East Campus, Shanghai, Peoples R China
[3] Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai, Peoples R China
[4] Shanghai Jiao Tong Univ, Sch Pharm, Shanghai, Peoples R China
来源：
FRONTIERS IN CHEMISTRY | 2017年 / 5卷
基金：
美国国家科学基金会;
关键词：
platelet-rich plasma; growth factors; stem cells; cell differentiation; musculoskeletal regeneration; CHONDROGENIC DIFFERENTIATION; PERIPHERAL-BLOOD; IN-VITRO; BONE; REPAIR; THERAPY; TENDON; VEGF; VASCULOGENESIS; PROLIFERATION;
D O I：
10.3389/fchem.2017.00089
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Stem cell treatment and platelet-rich plasma (PRP) therapy are two significant issues in regenerative medicine. Stem cells such as bone marrow mesenchymal stem cells, adipose-derived stem cells and periodontal ligament stem cells can be successfully applied in the field of tissue regeneration. PRP, a natural product isolated from whole blood, can secrete multiple growth factors (GFs) for regulating physiological activities. These GFs can stimulate proliferation and differentiation of different stem cells in injury models. Therefore, combination of both agents receives wide expectations in regenerative medicine, especially in bone, cartilage and tendon repair. In this review, we thoroughly discussed the interaction and underlying mechanisms of PRP derived GFs with stem cells, and assessed their functions in cell differentiation for musculoskeletal regeneration.
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页数：8
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