Clostridium difficile infection An overview of the disease and its pathogenesis, epidemiology and interventions

被引：89

作者：

Viswanathan, V. K. ^{[1
]}

Mallozzi, M. J. ^{[1
]}

Vedantam, Gayatri ^{[1
,2
]}

机构：

[1] Univ Arizona, Dept Vet Sci & Microbiol, Tucson, AZ 85721 USA

[2] Southern Arizona VA Healthcare Syst, Res Serv, Tucson, AZ 85723 USA

来源：

GUT MICROBES | 2010年 / 1卷 / 04期

关键词：

Clostridium difficile; infection; CDI; CDAD; hypervirulent; spore; infection control; pathogenesis;

D O I：

10.4161/gmic.1.4.12706

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Clostridium difficile infection (CDI) is the primary cause of antibiotic-associated diarrhea and is a significant nosocomial disease. In the past ten years, variant toxin-producing strains of C. difficile have emerged, that have been associated with severe disease as well as outbreaks worldwide. This review summarizes current information on C. difficile pathogenesis and disease, and highlights interventions used to combat single and recurrent episodes of CDI.

引用

收藏

页码：234 / 242

页数：9

相关论文

共 146 条

[1] Correlation of disease severity with fecal toxin levels in patients with Clostridium difficile-associated diarrhea and distribution of PCR ribotypes and toxin yields in vitro of corresponding isolates [J].

Åkerlund, T ;

Svenungsson, B ;

Lagergren, Å ;

Burman, LG .

JOURNAL OF CLINICAL MICROBIOLOGY, 2006, 44 (02) :353-358

[2] Increased sporulation rate of epidemic clostridium difficile type 027/NAP1 [J].

Akerlund, Thomas ;

Persson, Ingela ;

Unemo, Magnus ;

Noren, Torbjoern ;

Svenungsson, Bo ;

Wullt, Marlene ;

Burman, Lars G. .

JOURNAL OF CLINICAL MICROBIOLOGY, 2008, 46 (04) :1530-1533

[3] The distribution of Clostridium difficile in the environment of South Wales [J].

AlSaif, N ;

Brazier, JS .

JOURNAL OF MEDICAL MICROBIOLOGY, 1996, 45 (02) :133-137

[4] Antimicrobial activity of SMAP-29 against the Bacteroides fragilis group and clostridia [J].

Arzese, A ;

Skerlavaj, B ;

Tomasinsig, L ;

Gennaro, R ;

Zanetti, M .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2003, 52 (03) :375-381

[5] Emergence of reduced susceptibility to metronidazole in Clostridium difficile [J].

Baines, Simon D. ;

O'Connor, Rachael ;

Freeman, Jane ;

Fawley, Warren N. ;

Harmanus, Celine ;

Mastrantonio, Paola ;

Kuijper, Ed J. ;

Wilcox, Mark H. .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2008, 62 (05) :1046-1052

[6] Fecal bacteriotherapy for recurrent Clostridium difficile infection [J].

Bakken, Johan S. .

ANAEROBE, 2009, 15 (06) :285-289

[7] Clostridium difficile in Ready-to-Eat Salads, Scotland [J].

Bakri, Marwah M. ;

Brown, Derek J. ;

Butcher, John P. ;

Sutherland, Alistair D. .

EMERGING INFECTIOUS DISEASES, 2009, 15 (05) :817-818

[8] Clinical features of Clostridium difficile-associated infections and molecular characterization of strains:: Results of a retrospective study, 2000-2004 [J].

Barbut, Frederic ;

Gariazzo, Beatrice ;

Bonne, Laetitia ;

Lalande, Valerie ;

Burghoffer, Beatrice ;

Luiuz, Ralucca ;

Petit, Jean-Claude .

INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2007, 28 (02) :131-139

[9] Binary bacterial toxins:: Biochemistry, biology, and applications of common Clostridium and Bacillus proteins [J].

Barth, H ;

Aktories, K ;

Popoff, MR ;

Stiles, BG .

MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2004, 68 (03) :373-+

[10] Clostridium difficile: controversies and approaches to management [J].

Bauer, Martijn P. ;

van Dissel, Jaap T. ;

Kuijper, Ed J. .

CURRENT OPINION IN INFECTIOUS DISEASES, 2009, 22 (06) :517-524

← 1 2 3 4 5 6 7 8 9 10 →