The "Risk'' in Pediatric Low-Grade Glioma

被引:5
作者
Fangusaro, Jason [1 ,2 ,3 ]
Bandopadhayay, Pratiti [4 ,5 ,6 ]
机构
[1] Childrens Healthcare Atlanta, Dept Pediat Hematol & Oncol, Atlanta, GA 30329 USA
[2] Aflac Canc & Blood Disorder Ctr, Atlanta, GA 30322 USA
[3] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA
[4] Dana Farber Boston Childrens Canc & Blood Disorde, Boston, MA USA
[5] Broad Inst MIT & Harvard, Cambridge, MA 02142 USA
[6] Harvard Med Sch, Dept Pediat, Boston, MA 02115 USA
关键词
RECURRENT; CHILDREN;
D O I
10.1016/j.ccell.2020.03.020
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
In this issue of Cancer Cell, Ryall et al. report on the largest clinically and molecularly characterized cohort of pediatric low-grade gliomas (pLGGs) published to date. They provide new insight into the pLGG molecular landscape and a novel risk stratification system with the potential to revolutionize prognostication and impact treatment.
引用
收藏
页码:424 / 425
页数:2
相关论文
共 10 条
  • [1] Bandopadhayay P, 2014, PEDIATR BLOOD CANCER, V61, P1173, DOI 10.1002/pbc.24958
  • [2] Selumetinib in paediatric patients with BRAF-aberrant or neurofibromatosis type 1-associated recurrent, refractory, or progressive low-grade glioma: a multicentre, phase 2 trial
    Fangusaro, Jason
    Onar-Thomas, Arzu
    Poussaint, Tina Young
    Wu, Shengjie
    Ligon, Azra H.
    Lindeman, Neal
    Banerjee, Anuradha
    Packer, Roger J.
    Kilburn, Lindsay B.
    Goldman, Stewart
    Pollack, Ian F.
    Qaddoumi, Ibrahim
    Jakacki, Regina I.
    Fisher, Paul G.
    Dhall, Girish
    Baxter, Patricia
    Kreissman, Susan G.
    Stewart, Clinton F.
    Jones, David T. W.
    Pfister, Stefan M.
    Vezina, Gilbert
    Stern, Jessica S.
    Panigrahy, Ashok
    Patay, Zoltan
    Tamrazi, Benita
    Jones, Jeremy Y.
    Haque, Sofia S.
    Enterline, David S.
    Cha, Soonmee
    Fisher, Michael J.
    Doyle, Laurence Austin
    Smith, Malcolm
    Dunkel, Ira J.
    Fouladi, Maryam
    [J]. LANCET ONCOLOGY, 2019, 20 (07) : 1011 - 1022
  • [3] Exploiting molecular biology for diagnosis and targeted management of pediatric low-grade gliomas
    Garcia, Michael A.
    Solomon, David A.
    Haas-Kogan, Daphne A.
    [J]. FUTURE ONCOLOGY, 2016, 12 (12) : 1493 - 1506
  • [4] Recurrent somatic alterations of FGFR1 and NTRK2 in pilocytic astrocytoma
    Jones, David T. W.
    Hutter, Barbara
    Jaeger, Natalie
    Korshunov, Andrey
    Kool, Marcel
    Warnatz, Hans-Joerg
    Zichner, Thomas
    Lambert, Sally R.
    Ryzhova, Marina
    Dong Anh Khuong Quang
    Fontebasso, Adam M.
    Stuetz, Adrian M.
    Hutter, Sonja
    Zuckermann, Marc
    Sturm, Dominik
    Gronych, Jan
    Lasitschka, Baerbel
    Schmidt, Sabine
    Seker-Cin, Huriye
    Witt, Hendrik
    Sultan, Marc
    Ralser, Meryem
    Northcott, Paul A.
    Hovestadt, Volker
    Bender, Sebastian
    Pfaff, Elke
    Stark, Sebastian
    Faury, Damien
    Schwartzentruber, Jeremy
    Majewski, Jacek
    Weber, Ursula D.
    Zapatka, Marc
    Raeder, Benjamin
    Schlesner, Matthias
    Worth, Catherine L.
    Bartholomae, Cynthia C.
    von Kalle, Christof
    Imbusch, Charles D.
    Radomski, Sylwester
    Lawerenz, Chris
    van Sluis, Peter
    Koster, Jan
    Volckmann, Richard
    Versteeg, Rogier
    Lehrach, Hans
    Monoranu, Camelia
    Winkler, Beate
    Unterberg, Andreas
    Herold-Mende, Christel
    Milde, Till
    [J]. NATURE GENETICS, 2013, 45 (08) : 927 - U295
  • [5] Phase II study of sorafenib in children with recurrent or progressive low-grade astrocytomas
    Karajannis, Matthias A.
    Legault, Genevieve
    Fisher, Michael J.
    Milla, Sarah S.
    Cohen, Kenneth J.
    Wisoff, Jeffrey H.
    Harter, David H.
    Goldberg, Judith D.
    Hochman, Tsivia
    Merkelson, Amanda
    Bloom, Michael C.
    Sievert, Angela J.
    Resnick, Adam C.
    Dhall, Girish
    Jones, David T. W.
    Korshunov, Andrey
    Pfister, Stefan M.
    Eberhart, Charles G.
    Zagzag, David
    Allen, Jeffrey C.
    [J]. NEURO-ONCOLOGY, 2014, 16 (10) : 1408 - 1416
  • [6] Therapeutic and Prognostic Implications of BRAF V600E in Pediatric Low-Grade Gliomas
    Lassaletta, Alvaro
    Zapotocky, Michal
    Mistry, Matthew
    Ramaswamy, Vijay
    Honnorat, Marion
    Krishnatry, Rahul
    Stucklin, Ana Guerreiro
    Zhukova, Nataliya
    Arnoldo, Anthony
    Ryall, Scott
    Ling, Catriona
    McKeown, Tara
    Loukides, Jim
    Cruz, Ofelia
    de Torres, Carmen
    Ho, Cheng-Ying
    Packer, Roger J.
    Tatevossian, Ruth
    Qaddoumi, Ibrahim
    Harreld, Julie H.
    Dalton, James D.
    Mulcahy-Levy, Jean
    Foreman, Nicholas
    Karajannis, Matthias A.
    Wang, Shiyang
    Snuderl, Matija
    Rao, Amulya Nageswara
    Giannini, Caterina
    Kieran, Mark
    Ligon, Keith L.
    Garre, Maria Luisa
    Nozza, Paolo
    Mascelli, Samantha
    Raso, Alessandro
    Mueller, Sabine
    Nicolaides, Theodore
    Silva, Karen
    Perbet, Romain
    Vasiljevic, Alexandre
    Conter, Cecile Faure
    Frappaz, Didier
    Leary, Sarah
    Crane, Courtney
    Chan, Aden
    Ng, Ho-Keung
    Shi, Zhi-Feng
    Mao, Ying
    Finch, Elizabeth
    Eisenstat, David
    Wilson, Bev
    [J]. JOURNAL OF CLINICAL ONCOLOGY, 2017, 35 (25) : 2934 - +
  • [7] Packer R.J., 2020, NEURO-ONCOLOGY, DOI [10.1093/neuonc/noaa036, DOI 10.1093/NEUONC/NOAA036]
  • [8] Pediatric low-grade gliomas: implications of the biologic era
    Packer, Roger J.
    Pfister, Stephan
    Bouffet, Eric
    Avery, Robert
    Bandopadhayay, Pratiti
    Bornhorst, Miriam
    Bowers, Daniel C.
    Ellison, David
    Fangusaro, Jason
    Foreman, Nicholas
    Fouladi, Maryam
    Gajjar, Amar
    Haas-Kogan, Daphne
    Hawkins, Cynthia
    Ho, Cheng-Ying
    Hwang, Eugene
    Jabado, Nada
    Kilburn, Lindsay B.
    Lassaletta, Alvaro
    Ligon, Keith L.
    Massimino, Maura
    Meeteren, Schouten-van
    Mueller, Sabine
    Nicolaides, Theo
    Perilongo, Giorgio
    Tabori, Uri
    Vezina, Gilbert
    Warren, Katherine
    Witt, Olaf
    Zhu, Yuan
    Jones, David T.
    Kieran, Mark
    [J]. NEURO-ONCOLOGY, 2017, 19 (06) : 750 - 761
  • [9] Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas
    Ryall, Scott
    Zapotocky, Michal
    Fukuoka, Kohei
    Nobre, Liana
    Stucklin, Ana Guerreiro
    Bennett, Julie
    Siddaway, Robert
    Li, Christopher
    Pajovic, Sanja
    Arnoldo, Anthony
    Kowalski, Paul E.
    Johnson, Monique
    Sheth, Javal
    Lassaletta, Alvaro
    Tatevossian, Ruth G.
    Orisme, Wilda
    Qaddoumi, Ibrahim
    Surrey, Lea F.
    Li, Marilyn M.
    Waanders, Angela J.
    Gilheeney, Stephen
    Rosenblum, Marc
    Bale, Tejus
    Tsang, Derek S.
    Laperriere, Normand
    Kulkarni, Abhaya
    Ibrahim, George M.
    Drake, James
    Dirks, Peter
    Taylor, Michael D.
    Rutka, James T.
    Laughlin, Suzanne
    Shroff, Manohar
    Shago, Mary
    Hazrati, Lili-Naz
    D'Arcy, Colleen
    Ramaswamy, Vijay
    Bartels, Ute
    Huang, Annie
    Bouffet, Eric
    Karajannis, Matthias A.
    Santi, Mariarita
    Ellison, David W.
    Tabori, Uri
    Hawkins, Cynthia
    [J]. CANCER CELL, 2020, 37 (04) : 569 - +
  • [10] Whole-genome sequencing identifies genetic alterations in pediatric low-grade gliomas
    Zhang, Jinghui
    Wu, Gang
    Miller, Claudia P.
    Tatevossian, Ruth G.
    Dalton, James D.
    Tang, Bo
    Orisme, Wilda
    Punchihewa, Chandanamali
    Parker, Matthew
    Qaddoumi, Ibrahim
    Boop, Fredrick A.
    Lu, Charles
    Kandoth, Cyriac
    Ding, Li
    Lee, Ryan
    Huether, Robert
    Chen, Xiang
    Hedlund, Erin
    Nagahawatte, Panduka
    Rusch, Michael
    Boggs, Kristy
    Cheng, Jinjun
    Becksfort, Jared
    Ma, Jing
    Song, Guangchun
    Li, Yongjin
    Wei, Lei
    Wang, Jianmin
    Shurtleff, Sheila
    Easton, John
    Zhao, David
    Fulton, Robert S.
    Fulton, Lucinda L.
    Dooling, David J.
    Vadodaria, Bhavin
    Mulder, Heather L.
    Tang, Chunlao
    Ochoa, Kerri
    Mullighan, Charles G.
    Gajjar, Amar
    Kriwacki, Richard
    Sheer, Denise
    Gilbertson, Richard J.
    Mardis, Elaine R.
    Wilson, Richard K.
    Downing, James R.
    Baker, Suzanne J.
    Ellison, David W.
    [J]. NATURE GENETICS, 2013, 45 (06) : 602 - +