Dynamic structures in Escherichia coli: Spontaneous formation of MinE rings and MinD polar zones

被引：222

作者：

Huang, KC

Meir, Y

Wingreen, NS

机构：

[1] MIT, Dept Phys, Cambridge, MA 02139 USA

[2] NEC Labs Amer Inc, Princeton, NJ 08540 USA

[3] Ben Gurion Univ Negev, Dept Phys, IL-84105 Beer Sheva, Israel

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2003年 / 100卷 / 22期

关键词：

D O I：

10.1073/pnas.2135445100

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

In Escherichia coli, division site selection is regulated in part by the Min-protein system. Oscillations of the Min proteins from pole to pole every approximate to40 sec have been revealed by in vivo studies of GFP fusions. The dynamic oscillatory structures produced by the Min proteins, including a ring of MinE protein, compact polar zones of MinD, and zebra-striped oscillations in filamentous cells, remain unexplained. We show that the Min oscillations, including mutant phenotypes, can be accounted for by in vitro-observed interactions involving MinD and MinE, with a crucial role played by the rate of nucleotide exchange. Recent discoveries suggest that protein oscillations may play a general role in proper chromosome and plasmid partitioning.

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页码：12724 / 12728

页数：5

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