Effects of exposure to organic solvents an menstrual cycle length

被引:42
作者
Cho, SI
Damokosh, AI
Ryan, LM
Chen, DF
Hu, YA
Smith, TJ
Christiani, DC
Xu, XP
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Environm Hlth, Program Populat Genet, Boston, MA 02115 USA
[2] Harvard Univ, Sch Publ Hlth, Dept Biostat, Boston, MA 02115 USA
[3] Beijing Med Univ, Beijing, Peoples R China
[4] Res Triangle Inst, Res Triangle Pk, NC 27709 USA
关键词
D O I
10.1097/00043764-200106000-00012
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
To investigate the association between organic solvent exposure and menstrual disturbance, we conducted a cross-sectional study among 1408 petrochemical workers in China. Based on an industrial hygiene evaluation, we classified the workshops according to the presence or absence of organic solvents (benzene, styrene, toluene, or xylene). We used logistic regression to estimate odds ratios and 95% confidence intervals for prolonged menstrual cycle length (oligomenorrhea: average cycle length >35 days during the previous year) associated with the exposure. After adjustment for confounders, each additional year of work in an exposed workshop was associated with a 7% increase in oligomenorrhea (odds ratio, 1.07; 95% confidence interval, 1.00 to 1.14). Compared with no exposure, 3 or more years of exposure was associated with a 53% increase in oligomenorrhea (odds ratio, 1.53, 95% confidence interval, 1.00 to 2.34). We concluded that exposure to organic solvents is associated with a trend toward increased frequency of oligomenorrhea.
引用
收藏
页码:567 / 575
页数:9
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