Drug Delivery to the Posterior Segment of the Eye: Biopharmaceutic and Pharmacokinetic Considerations

被引：249

作者：

Varela-Fernandez, Ruben ^{[1
,2
]}

Diaz-Tome, Victoria ^{[1
,3
]}

Luaces-Rodriguez, Andrea ^{[1
,3
]}

Conde-Penedo, Andrea ^{[1
,4
]}

Garcia-Otero, Xurxo ^{[1
,5
]}

Luzardo-Alvarez, Asteria ^{[1
,4
]}

Fernandez-Ferreiro, Anxo ^{[1
,3
]}

Otero-Espinar, Francisco J. ^{[1
,4
]}

机构：

[1] Univ Santiago de Compostela, Dept Pharmacol Pharm & Pharmaceut Technol, Campus Vida, Santiago De Compostela 15782, Spain

[2] Univ Clin Hosp, Clin Neurosci Grp, Hlth Res Inst Santiago de Compostela IDIS, Travesia Choupana S-N, Santiago De Compostela 15706, Spain

[3] Hlth Res Inst Santiago de Compostela IDIS, Clin Pharmacol Grp, Univ Clin Hosp, Travesia Choupana S-N, Santiago De Compostela 15706, Spain

[4] Hlth Res Inst Santiago de Compostela IDIS, Paraquasil Grp, Travesia Choupana S-N, Santiago De Compostela 15706, Spain

[5] Hlth Res Inst Santiago de Compostela IDIS, Univ Clin Hosp, Mol Imaging Grp, Travesia Choupana S-N, Santiago De Compostela 15706, Spain

来源：

PHARMACEUTICS | 2020年 / 12卷 / 03期

关键词：

ocular pharmacokinetics; ocular drug delivery systems; ocular routes of drug administration; intravitreal administration; topical administration; BLOOD-RETINAL BARRIER; HUMAN SCLERAL PERMEABILITY; INTRAVITREAL INJECTION; VITREOUS-HUMOR; SUSTAINED-RELEASE; MOLECULAR-WEIGHT; AQUEOUS-HUMOR; SUBCONJUNCTIVAL INJECTION; TRIAMCINOLONE ACETONIDE; OCULAR PHARMACOKINETICS;

D O I：

10.3390/pharmaceutics12030269

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The treatment of the posterior-segment ocular diseases, such as age-related eye diseases (AMD) or diabetic retinopathy (DR), present a challenge for ophthalmologists due to the complex anatomy and physiology of the eye. This specialized organ is composed of various static and dynamic barriers that restrict drug delivery into the target site of action. Despite numerous efforts, effective intraocular drug delivery remains unresolved and, therefore, it is highly desirable to improve the current treatments of diseases affecting the posterior cavity. This review article gives an overview of pharmacokinetic and biopharmaceutics aspects for the most commonly-used ocular administration routes (intravitreal, topical, systemic, and periocular), including information of the absorption, distribution, and elimination, as well as the benefits and limitations of each one. This article also encompasses different conventional and novel drug delivery systems designed and developed to improve drug pharmacokinetics intended for the posterior ocular segment treatment.

引用

页数：39

共 219 条

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