Selinexor-based regimens for the treatment of myeloma refractory to chimeric antigen receptor T cell therapy

被引：15

作者：

Chari, Ajai ^{[1
]}

Vogl, Dan T. ^{[2
]}

Jagannath, Sundar ^{[1
]}

Jasielec, Jagoda ^{[3
]}

Unger, Thaddeus J. ^{[4
]}

DeCastro, Andrew ^{[4
]}

Shah, Jatin ^{[4
]}

Kauffman, Michael ^{[4
]}

Shacham, Sharon ^{[4
]}

Jakubowiak, Andrzej ^{[3
]}

机构：

[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[2] Univ Penn, Abramson Canc Ctr, Perelman Sch Med, Philadelphia, PA 19104 USA

[3] Univ Chicago, Med Ctr, Chicago, IL 60637 USA

[4] Karyopharm Therapeut, Newton, MA USA

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2020年 / 189卷 / 04期

关键词：

selinexor; chimeric antigen receptor T cell refractory; multiple myeloma; carfilomib; bortezomib; ORAL SELINEXOR;

D O I：

10.1111/bjh.16550

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

引用

页码：E124 / E128

页数：5

共 14 条

[1]

Abdul Razak A.R., 2016, J CLIN ONCOLOGY OFFI, V36, P859

[2]

Argueta Christian, 2018, Oncotarget, V9, P25529, DOI 10.18632/oncotarget.25368

[3] Selinexor plus low-dose bortezomib and dexamethasone for patients with relapsed or refractory multiple myeloma [J].

Bahlis, Nizar J. ;

Sutherland, Heather ;

White, Darrell ;

Sebag, Michael ;

Lentzsch, Suzanne ;

Kotb, Rami ;

Venner, Christopher P. ;

Gasparetto, Cristina ;

Del Col, Aldo ;

Neri, Paola ;

Reece, Donna ;

Kauffman, Michael ;

Shacham, Sharon ;

Unger, T. J. ;

Jeha, Jacqueline ;

Saint-Martin, Jean-Richard ;

Shah, Jatin ;

Chen, Christine .

BLOOD, 2018, 132 (24) :2546-2554

[4] Oral Selinexor-Dexamethasone for Triple-Class Refractory Multiple Myeloma [J].

Chari, Ajai ;

Vogl, Dan T. ;

Gavriatopoulou, Maria ;

Nooka, Ajay K. ;

Yee, Andrew J. ;

Huff, Carol A. ;

Moreau, Philippe ;

Dingli, David ;

Cole, Craig ;

Lonial, Sagar ;

Dimopoulos, Meletios ;

Stewart, A. Keith ;

Richter, Joshua ;

Vij, Ravi ;

Tuchman, Sascha ;

Raab, Marc S. ;

Weisel, Katja C. ;

Delforge, Michel ;

Cornell, Robert F. ;

Kaminetzky, David ;

Hoffman, James E. ;

Costa, Luciano J. ;

Parker, Terri L. ;

Levy, Moshe ;

Schreder, Martin ;

Meuleman, Nathalie ;

Frenzel, Laurent ;

Mohty, Mohamad ;

Choquet, Sylvain ;

Schiller, Gary ;

Comenzo, Raymond L. ;

Engelhardt, Monika ;

Illmer, Thomas ;

Vlummens, Philip ;

Doyen, Chantal ;

Facon, Thierry ;

Karlin, Lionel ;

Perrot, Aurore ;

Podar, Klaus ;

Kauffman, Michael G. ;

Shacham, Sharon ;

Li, Lingling ;

Tang, Shijie ;

Picklesimer, Carla ;

Saint-Martin, Jean-Richard ;

Crochiere, Marsha ;

Chang, Hua ;

Parekh, Samir ;

Landesman, Yosef ;

Shah, Jatin .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 381 (08) :727-738

[5] Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia [J].

Chen, Christine ;

Siegel, David ;

Gutierrez, Martin ;

Jacoby, Meagan ;

Hofmeister, Craig C. ;

Gabrail, Nashat ;

Baz, Rachid ;

Mau-Sorensen, Morten ;

Berdeja, Jesus G. ;

Savona, Michael ;

Savoie, Lynn ;

Trudel, Suzanne ;

Areethamsirikul, Nuchanan ;

Unger, T. J. ;

Rashal, Tami ;

Hanke, Tim ;

Kauffman, Michael ;

Shacham, Sharon ;

Reece, Donna .

BLOOD, 2018, 131 (08) :855-863

[6] BCMA CAR T-cell therapy arrives for multiple myeloma: a reality [J].

Cho, Shih-Feng ;

Anderson, Kenneth C. ;

Tai, Yu-Tzu .

ANNALS OF TRANSLATIONAL MEDICINE, 2018, 6

[7]

Jakubowiak A.J., 2019, BRIT J HAEMATOL, V132, P2546

[8] Selinexor, a Selective Inhibitor of Nuclear Export (SINE) compound, acts through NF-κB deactivation and combines with proteasome inhibitors to synergistically induce tumor cell death [J].

Kashyap, Trinayan ;

Argueta, Christian ;

Aboukameel, Amro ;

Unger, Thaddeus John ;

Klebanov, Boris ;

Mohammad, Ramzi M. ;

Muqbil, Irfana ;

Azmi, Asfar S. ;

Drolen, Claire ;

Senapedis, William ;

Lee, Margaret ;

Kauffman, Michael ;

Shacham, Sharon ;

Landesman, Yosef .

ONCOTARGET, 2016, 7 (48) :78883-78895

[9] Anti-BCMA CAR T-Cell Therapy bb2121 in Relapsed or Refractory Multiple Myeloma [J].

Raje, Noopur ;

Berdeja, Jesus ;

Lin, Yi ;

Siegel, David ;

Jagannath, Sundar ;

Madduri, Deepu ;

Liedtke, Michaela ;

Rosenblatt, Jacalyn ;

Maus, Marcela V. ;

Turka, Ashley ;

Lam, Lyh-Ping ;

Morgan, Richard A. ;

Friedman, Kevin ;

Massaro, Monica ;

Wang, Julie ;

Russotti, Greg ;

Yang, Zhihong ;

Campbell, Timothy ;

Hege, Kristen ;

Petrocca, Fabio ;

Quigley, M. Travis ;

Munshi, Nikhil ;

Kochenderfer, James N. .

NEW ENGLAND JOURNAL OF MEDICINE, 2019, 380 (18) :1726-1737

[10] The comprehensive clinical management of multiple myeloma and related-plasma cell disorders [J].

Richardson, Paul G. ;

Blade, Joan .

EXPERT REVIEW OF HEMATOLOGY, 2014, 7 (01) :1-3

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