A proposal for identifying the low renal uric acid clearance phenotype

被引：11

作者：

Indraratna, Praveen L. ^{[1
]}

Stocker, Sophie L. ^{[2
,3
]}

Williams, Kenneth M. ^{[1
]}

Graham, Garry G. ^{[1
]}

Jones, Graham ^{[4
]}

Day, Richard O. ^{[1
]}

机构：

[1] St Vincents Hosp, Dept Clin Pharmacol & Toxicol, Sydney, NSW 2010, Australia

[2] Univ New S Wales, Fac Med, Inst Hlth Innovat, Sydney, NSW 2052, Australia

[3] Univ Sydney, Fac Pharm, Sydney, NSW 2006, Australia

[4] St Vincents Hosp, Dept Chem Pathol, Sydney, NSW 2010, Australia

来源：

ARTHRITIS RESEARCH & THERAPY | 2010年 / 12卷 / 06期

关键词：

URATE TRANSPORTER; GOUT; EXCRETION; HYPERURICEMIA; ASSOCIATION; SLC2A9; SERUM;

D O I：

10.1186/ar3191

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Investigation of the genetic basis of hyperuricaemia is a subject of intense interest. However, clinical studies commonly include hyperuricaemic patients without distinguishing between 'over-producers' or 'under-excretors' of urate. The statistical power of studies of genetic polymorphisms of genes encoding renal urate transporters is diluted if 'over-producers' of uric acid are included. We propose that lower than normal fractional renal clearance of urate is a better inclusion criterion for these studies. We also propose that a single daytime spot urine sample for calculation of fractional renal clearance of urate should be preferred to calculation from 24-hour urine collections.

引用

页数：3

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