Inhibitory Activity of Plantago major L. on Angiotensin I-converting Enzyme

被引：9

作者：

Nguyen Xuan Nhiem ^{[1
,2
]}

Tai, Bui Huu ^{[1
,2
]}

Phan Van Kiem ^{[2
]}

Chau Van Minh ^{[2
]}

Nguyen Xuan Cuong ^{[2
]}

Nguyen Huu Tung ^{[1
,2
]}

Vu Kim Thu ^{[2
]}

Trinh Nam Trung ^{[1
]}

Anh, Hoang Le Tuan ^{[1
]}

Jo, Sung-Hoon ^{[3
]}

Jang, Hae-Dong ^{[3
]}

Kwon, Young-In ^{[3
]}

Kim, Young Ho ^{[1
]}

机构：

[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[2] Vietnam Acad Sci & Technol VAST, Inst Marine Biochem, Hanoi, Vietnam

[3] Hannam Univ, Dept Food & Nutr, Taejon 305811, South Korea

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2011年 / 34卷 / 03期

基金：

新加坡国家研究基金会;

关键词：

Angiotensin I-converting enzyme; Antihypertensive effect; Plantago major; GLYCOSIDES;

D O I：

10.1007/s12272-011-0309-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eight compounds were isolated from methanol extract of Plantago major L. leaves and investigated for their ability to inhibit angiotensin I-converting enzyme activity. Among them, compound 1 showed the most potent inhibition with rate of 28.06 +/- 0.21% at a concentration of 100 mu M. Compounds 2 and 8 exhibited weak activities. These results suggest that compound 1 might contribute to the ability of P. major to inhibit the activity of angiotensin I- converting enzyme.

引用

页码：419 / 423

页数：5

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