An Investigation of the Prescription Patterns of Chinese Herbal Products for Chronic Glomerulonephritis Patients: A Hospital-Based Cross-Sectional Study

被引：21

作者：

Chen, Wen ^{[1
,2
]}

Chen, Hsing-Yu ^{[1
,3
,4
]}

Yang, Yao-Hsu ^{[5
,6
,7
]}

Yang, Sien-Hung ^{[1
,3
,8
,9
]}

Yang, Ching-Wei ^{[1
,3
]}

Wu, You-Hung ^{[10
]}

Chen, Jiun-Liang ^{[1
,3
]}

机构：

[1] Chang Gung Mem Hosp, Ctr Tradit Chinese Med, Div Chinese Internal Med, Taoyuan, Taiwan

[2] China Med Univ, Sch Chinese Med, Taichung, Taiwan

[3] Chang Gung Univ, Sch Tradit Chinese Med, Coll Med, Taoyuan, Taiwan

[4] Chang Gung Univ, Grad Inst Clin Med Sci, Coll Med, Taoyuan, Taiwan

[5] Chang Gung Mem Hosp, Dept Tradit Chinese Med, Chiayi, Taiwan

[6] Natl Taiwan Univ, Coll Publ Hlth, Inst Occupat Med & Ind Hyg, Taipei, Taiwan

[7] Chang Gung Mem Hosp, Ctr Excellence Chang Gung Res Data Link, Chiayi, Taiwan

[8] Chang Gung Mem Hosp, Chang Gung Immunol Consortium, Taoyuan, Taiwan

[9] Chang Gung Univ, Taoyuan, Taiwan

[10] China Med Univ, Coll Med, Grad Inst Acupuncture Sci, Taichung, Taiwan

来源：

EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE | 2018年 / 2018卷

关键词：

CHRONIC KIDNEY-DISEASE; ASTRAGALUS-MEMBRANACEUS; RADIX-ASTRAGALI; RENAL-DISEASE; IN-VITRO; MEDICINE; RISK; TANG; INHIBITOR; EFFICACY;

D O I：

10.1155/2018/5080764

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Chronic kidney disease (CKD) has a high incidence and prevalence worldwide, and chronic glomerulonephritis (CGN) is one of the main causes of CKD. Therefore, it is important to diagnose and treat CGN early. The purpose of this study is to analyze the prescription patterns and frequencies of Chinese herbal products (CHPs) for CGN by using a hospital-based database from the Chang Gung Memorial Hospital (CGMH), a large, tertiary hospital system in Taiwan, and to evaluate the safety and possible efficacy of CHPs by blood test. The International Classification of Disease Ninth Revision (ICD-9) code 582 was used to identify patients with CGN. From 2004 to 2015, a total of 54726 CHP prescriptions for CGN were provided. Association rule mining was used to analyze the prevalent of CHP combination patterns in treating CGN. Jia-Wei-Xiao-Yao-San (JWXYS) and Gorgon (Euryale feroxSalisb.) were the most frequently prescribed herbal formula (HF) and single herb (SH), respectively. The most frequently prescribed combination of CHPs was that of JWXYS with Bu-Yang-Huan-Wu-Tang (BYHWT) in CGMH. In statistical, the level of eGFR in Stage 3a and 3b group was increasing after treatment in 6 and 12 months and might not cause the renal function to worsen within 12-month treatments. To the best of our knowledge, this is the first pharmacoepidemiological study to review CHP treatments for CGN. However, additional studies and clinical trials are needed to provide data on the safety and efficacy of these CHPs.

引用

页数：11

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