Synthesis of Gal beta 1-4GlcNAc beta- and Gal beta 1-3GalNAc alpha-O-L-serine derivatives employing glycosidases

被引：10
作者：
Nilsson, KGI
机构：
[1] Glycorex A.B., S-223 70 Lund
来源：
BIOTECHNOLOGY LETTERS | 1996年 / 18卷 / 07期
关键词：
D O I：
10.1007/BF00127890
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
A new approach for the highly specific preparation of L-serine conjugates of lactosamine and Ga1 beta 1-3GalNAc is described. Thus, the L serine derivative of lactosamine Ga1 beta 1-4GlcNAc beta-O-(N-Z)-Ser-OEt, was obtained from lactose, employing GlcNAc beta-O-(N-Z)-Ser-OEt as acceptor and a yeast beta-galactosidase as catalyst. Ga1 beta 1-3GalNAc alpha-O-(N-Alloc)-Ser-OMe was obtained from lactose, employing GalNAc alpha-O-(N-Alloc)-Ser-OMe as acceptor and beta-galactosidase from bovine testes as catalyst.
引用
收藏
页码：791 / 794
页数：4
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