ANTI-INFLAMMATORY AND STRUCTURE PROTECTIVE EFFECTS OF HYALURONANS: ARE THESE EFFECTS MOLECULAR WEIGHT DEPENDENT?

被引:5
作者
Huang, Teng-Le [1 ,2 ,3 ]
Hsu, Horng-Chaung [1 ]
Yao, Chun-Hsu [4 ]
Chen, Yueh-Sheng [5 ]
Wang, Jeff [6 ]
机构
[1] China Med Univ, Coll Hlth Care, Dept Sports Med, Taichung 404, Taiwan
[2] Natl Taiwan Univ, Coll Med, Inst Biomed Engn, Taipei 10764, Taiwan
[3] Natl Taiwan Univ, Coll Engn, Taipei 10764, Taiwan
[4] China Med Univ, Dept Biomed Imaging & Radiol Sci, Taichung 404, Taiwan
[5] China Med Univ, Sch Chinese Med, Lab Biomat, Taichung 404, Taiwan
[6] Met Ind Res & Dev Ctr, Kaohsiung, Taiwan
来源
BIOMEDICAL ENGINEERING-APPLICATIONS BASIS COMMUNICATIONS | 2011年 / 23卷 / 01期
关键词
Hyaluronans; Inflammatory; Molecular weight; Structure protective; SODIUM HYALURONATE; INTRAARTICULAR INJECTION; MODIFYING ACTIVITY; SYNOVIAL-FLUID; CLINICAL-TRIAL; OSTEOARTHRITIS; KNEE; HYALGAN(R); EFFICACY; ACID;
D O I
10.4015/S1016237211002323
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Although hyaluronans (HA) has been proved to be effective in the treatment of patients with osteoarthritis and rheumatoid arthritis, the correlations between these effects and the molecular weight (MW) of HA have not been systematically followed. Many different HA preparations are now applied worldwide in clinical usage. Their MWs are very wide ranged (500-6,000 kDa). No systematic review especially addresses the role of HA's MW in the effects of anti-inflammation and structure protection. This study evaluates the literature of the basic and clinical studies on biological, pathological, and clinical effects of different MW HA. Databases were searched through PubMed (period 1978-2009), using the terms hyaluronan, hyaluronic acid, arthritis, and MW. Reference lists of relevant articles were controlled for additional references. We define the "high" MW (HMW) as MW greater than 2,000 kDa and define the "low" MW (LMW) as MW less than 2,000 kDa in the current study. Most data that support the structure protective effect of HA are from the studies with LMW HA. On the other hand, the majority of data that recommend the anti-inflammatory effect of HA are from the reports of HMW HA. In conclusion, we suggest that the effects of LMW HA were more structure protective and those of HMW HA were more anti-inflammatory.
引用
收藏
页码:13 / 20
页数:8
相关论文
共 33 条
  • [1] Abatangelo G., 1995, European Journal of Rheumatology and Inflammation, V15, P9
  • [2] Design and conduct of clinical trials in patients with osteoarthritis: Recommendations from a task force of the Osteoarthritis Research Society - Results from a workshop
    Altman, R
    Brandt, K
    Hochberg, M
    MOskowitz, R
    Bellamy, N
    Bloch, DA
    Buckwalter, J
    Dougados, M
    Ehrlich, G
    Lequesne, M
    Lohmander, S
    Murphy, WA
    RosarioJansen, T
    Schwartz, B
    Trippel, S
    [J]. OSTEOARTHRITIS AND CARTILAGE, 1996, 4 (04) : 217 - 243
  • [3] Altman RD, 1998, J RHEUMATOL, V25, P2203
  • [4] Long-term effect of sodium hyaluronate (Hyalgan®) on osteoarthritis progression in a rabbit model
    Amiel, D
    Toyoguchi, T
    Kobayashi, K
    Bowden, K
    Amiel, ME
    Healey, RM
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2003, 11 (09) : 636 - 643
  • [5] RETRACTED: Differential effect of molecular mass hyaluronan on lipopolysaccharide-induced damage in chondrocytes (Retracted Article)
    Campo, Giuseppe M.
    Avenoso, Angela
    Campo, Salvatore
    D'Ascola, Angela
    Traina, Paola
    Rugolo, Carmela A.
    Calatroni, Alberto
    [J]. INNATE IMMUNITY, 2010, 16 (01) : 48 - 63
  • [6] The six hyaluronidase-like genes in the human and mouse genomes
    Csoka, AB
    Frost, GI
    Stern, R
    [J]. MATRIX BIOLOGY, 2001, 20 (08) : 499 - 508
  • [7] CONCENTRATION AND MOLECULAR-WEIGHT OF SODIUM HYALURONATE IN SYNOVIAL-FLUID FROM PATIENTS WITH RHEUMATOID-ARTHRITIS AND OTHER ARTHROPATHIES
    DAHL, LB
    DAHL, IMS
    ENGSTROMLAURENT, A
    GRANATH, K
    [J]. ANNALS OF THE RHEUMATIC DISEASES, 1985, 44 (12) : 817 - 822
  • [8] Effects of hyaluronan on three-dimensional microarchitecture of subchondral bone tissues in guinea pig primary osteoarthrosis
    Ding, M
    Danielsen, CC
    Hvid, I
    [J]. BONE, 2005, 36 (03) : 489 - 501
  • [9] Fam H, 2007, BIORHEOLOGY, V44, P59
  • [10] Hyaluronans in the treatment of osteoarthritis of the knee: evidence for disease-modifying activity
    Goldberg, VM
    Buckwalter, JA
    [J]. OSTEOARTHRITIS AND CARTILAGE, 2005, 13 (03) : 216 - 224