Novel development of 5-aminolevurinic acid (ALA) in cancer diagnoses and therapy

被引：208
作者：
Ishizuka, Masahiro [1 ,2 ]
Abe, Fuminori [1 ]
Sano, Yuki [1 ]
Takahashi, Kiwamu [1 ]
Inoue, Katsushi [1 ]
Nakajima, Motowo [1 ]
Kohda, Takeo [1 ]
Komatsu, Naoki [1 ]
Ogura, Shun-ichiro [3 ]
Tanaka, Tohru [1 ]
机构：
[1] SBI Strateg Business Innovator ALApromo Co Ltd, Minato Ku, Tokyo 1066018, Japan
[2] Cosmo Oil Co LTD, Int Venture Dept, Minato Ku, Tokyo 1058528, Japan
[3] Tokyo Inst Technol, Integrated Res Inst, Midori Ku, Yokohama, Kanagawa 2268501, Japan
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2011年 / 11卷 / 03期
关键词：
5-aminolevulinic acid (ALA); Protoporphyrin IX (PpIX); Photodynamic diagnosis (POD); Photodynamic therapy (PDT); Hyperthermia; Immunotherapy; Dendritic cell vaccine; PROTOPORPHYRIN-IX-ACCUMULATION; CARBON-MONOXIDE SUPPRESS; DELTA-AMINOLAEVULIC ACID; NITRIC-OXIDE SYNTHASE; PHOTODYNAMIC THERAPY; HEME OXYGENASE-1; (ALA)-INDUCED PHOTOSENSITIVITY; LOCAL HYPERTHERMIA; NORMAL PATHWAYS; SOLID TUMORS;
D O I：
10.1016/j.intimp.2010.11.029
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Early detection and intervention are needed for optimal outcomes in cancer therapy. Improvements in diagnostic technology, including endoscopy, photodynamic diagnosis (PDD), and photodynamic therapy (PDT), have allowed substantial progress in the treatment of cancer. 5-Aminolevulinic acid (ALA) is a natural, delta amino acid biosynthesized by animal and plant mitochondria. ALA is a precursor of porphyrin, heme, and bile pigments, and it is metabolized into protoporphyrin IX (PpIX) in the course of heme synthesis. PpIX preferentially accumulates in tumor cells resulting in a red fluorescence following irradiation with violet light and the formation of singlet oxygen. This reaction, utilized to diagnose and treat cancer, is termed ALA-induced PDD and PDT. In this review, the biological significance of heme metabolites, the mechanism of PpIX accumulation in tumor cells, and the therapeutic potential of ALA-induced PDT alone and combined with hyperthermia and immunotherapy are discussed. (c) 2010 Elsevier B.V. All rights reserved.
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页码：358 / 365
页数：8
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