Vanillin Attenuated Behavioural Impairments, Neurochemical Deficts, Oxidative Stress and Apoptosis Against Rotenone Induced Rat Model of Parkinson's Disease

被引：80
作者：
Dhanalakshmi, Chinnasamy [1 ]
Janakiraman, Udaiyappan [1 ]
Manivasagam, Thamilarasan [1 ]
Thenmozhi, Arokiasamy Justin [1 ]
Essa, Musthafa Mohamed [2 ,3 ,4 ]
Kalandar, Ameer [5 ]
Khan, Mohammed Abdul Sattar [6 ]
Guillemin, Gilles J. [7 ]
机构：
[1] Annamalai Univ, Dept Biochem & Biotechnol, Chidambaram 608002, Tamil Nadu, India
[2] Sultan Qaboos Univ, Dept Food Sci & Nutr, CAMS, Muscat, Oman
[3] Sultan Qaboos Univ, Ageing & Dementia Res Grp, Muscat, Oman
[4] Food & Brain Res Fdn, Madras 600094, Tamil Nadu, India
[5] Haramaya Univ, Coll Hlth & Med Sci, Dire Dawa, Ethiopia
[6] Harvard Med Sch, Dept Anathesia, Boston, MA USA
[7] Macquarie Univ, Australian Sch Adv Med, Neuropharmacol Grp, MND & Neurodegenerat Dis Res Ctr, Balaclava Rd, Sydney, NSW 2109, Australia
来源：
NEUROCHEMICAL RESEARCH | 2016年 / 41卷 / 08期
关键词：
Parkinson's disease; Vanillin; Oxidative stress; apoptosis; Motor and non-motor symptoms; ELEVATED PLUS-MAZE; SUBSTANTIA-NIGRA; PROTECTIVE ROLE; CELL-DEATH; MICE; ANTIDEPRESSANT; BRAIN; NEURODEGENERATION; PEROXIDATION; ANTIOXIDANT;
D O I：
10.1007/s11064-016-1901-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Vanillin (4-hydroxy-3-methoxybenzaldehyde), a pleasant smelling organic aromatic compound, is widely used as a flavoring additive in food, beverage, cosmetic and drug industries. It is reported to cross the blood brain barrier and also displayed antioxidant and neuroprotective activities. We previously reported the neuroprotective effect of vanillin against rotenone induced in in vitro model of PD. The present experiment was aimed to analyze the neuroprotective effect of vanillin on the motor and non-motor deficits, neurochemical variables, oxidative, anti-oxidative indices and the expression of apoptotic markers against rotenone induced rat model of Parkinson's disease (PD). Rotenone treatment exhibited motor and non-motor impairments, neurochemical deficits, oxidative stress and apoptosis, whereas oral administration of vanillin attenuated the above-said indices. However further studies are needed to explore the mitochondrial protective and anti-inflammatory properties of vanillin, as these processes play a vital role in the cause and progression of PD.
引用
收藏
页码：1899 / 1910
页数：12
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