Steric Modulation of Ionic Currents in DNA Translocation Through Nanopores

被引：1
作者：
Mazzone, Valerio [1 ]
Melchionna, Simone [2 ]
Marconi, Umberto Marini Bettolo [3 ]
机构：
[1] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy
[2] CNR, IPCF, Rome, Italy
[3] Univ Camerino, INFN Perugia, Scuola Sci & Tecnol, I-62032 Camerino, Italy
来源：
JOURNAL OF STATISTICAL PHYSICS | 2015年 / 158卷 / 05期
关键词：
DNA translocation; Ionic current; Electrokinetics; Poisson-Nernst-Planck; NERNST-PLANCK; CONDUCTION; TRANSPORT;
D O I：
10.1007/s10955-014-1159-8
中图分类号：
O4 [物理学];
学科分类号：
0702 ;
摘要：
Ionic currents accompanying DNA translocation strongly depend on molarity of the electrolyte solution and the shape and surface charge of the nanopore. By means of the Poisson-Nernst-Planck equations it is shown how conductance is modulated by the presence of the DNA intruder and as a result of competing electrostatic and confinement factors. The theoretical results reproduce quantitatively the experimental ones and are summarized in a conductance diagram that allows distinguishing the region of reduced conductivity from the region of enhanced conductivity as a function of molarity and the pore dimension.
引用
收藏
页码：1181 / 1194
页数：14
相关论文
共 32 条
  • [1] Nanofluidics, from bulk to interfaces
    Bocquet, Lyderic
    Charlaix, Elisabeth
    [J]. CHEMICAL SOCIETY REVIEWS, 2010, 39 (03) : 1073 - 1095
  • [2] The potential and challenges of nanopore sequencing
    Branton, Daniel
    Deamer, David W.
    Marziali, Andre
    Bayley, Hagan
    Benner, Steven A.
    Butler, Thomas
    Di Ventra, Massimiliano
    Garaj, Slaven
    Hibbs, Andrew
    Huang, Xiaohua
    Jovanovich, Stevan B.
    Krstic, Predrag S.
    Lindsay, Stuart
    Ling, Xinsheng Sean
    Mastrangelo, Carlos H.
    Meller, Amit
    Oliver, John S.
    Pershin, Yuriy V.
    Ramsey, J. Michael
    Riehn, Robert
    Soni, Gautam V.
    Tabard-Cossa, Vincent
    Wanunu, Meni
    Wiggin, Matthew
    Schloss, Jeffery A.
    [J]. NATURE BIOTECHNOLOGY, 2008, 26 (10) : 1146 - 1153
  • [3] Translocation of nanoparticles through a polymer brush-modified nanochannel
    Cao, Qianqian
    Zuo, Chuncheng
    Li, Lujuan
    Li, Yingjie
    Yang, Yang
    [J]. BIOMICROFLUIDICS, 2012, 6 (03):
  • [4] A Poisson/Nernst-Planck model for ionic transport through synthetic conical nanopores
    Cervera, J
    Schiedt, B
    Ramírez, P
    [J]. EUROPHYSICS LETTERS, 2005, 71 (01): : 35 - 41
  • [5] Solid-state nanopores
    Dekker, Cees
    [J]. NATURE NANOTECHNOLOGY, 2007, 2 (04) : 209 - 215
  • [6] The electroneutrality approximation in electrochemistry
    Dickinson, Edmund J. F.
    Limon-Petersen, Juan G.
    Compton, Richard G.
    [J]. JOURNAL OF SOLID STATE ELECTROCHEMISTRY, 2011, 15 (7-8) : 1335 - 1345
  • [7] Detecting single stranded DNA with a solid state nanopore
    Fologea, D
    Gershow, M
    Ledden, B
    McNabb, DS
    Golovchenko, JA
    Li, JL
    [J]. NANO LETTERS, 2005, 5 (10) : 1905 - 1909
  • [8] Ghosal S., 2012, ARXIV12031945
  • [9] Effect of salt concentration on the electrophoretic speed of a polyelectrolyte through a nanopore
    Ghosal, Sandip
    [J]. PHYSICAL REVIEW LETTERS, 2007, 98 (23)
  • [10] Electrophoresis of a polyelectrolyte through a nanopore
    Ghosal, Sandip
    [J]. PHYSICAL REVIEW E, 2006, 74 (04):
1234