Steric Modulation of Ionic Currents in DNA Translocation Through Nanopores

被引：1

作者：

Mazzone, Valerio ^{[1
]}

Melchionna, Simone ^{[2
]}

Marconi, Umberto Marini Bettolo ^{[3
]}

机构：

[1] Univ Roma La Sapienza, Dipartimento Fis, I-00185 Rome, Italy

[2] CNR, IPCF, Rome, Italy

[3] Univ Camerino, INFN Perugia, Scuola Sci & Tecnol, I-62032 Camerino, Italy

来源：

JOURNAL OF STATISTICAL PHYSICS | 2015年 / 158卷 / 05期

关键词：

DNA translocation; Ionic current; Electrokinetics; Poisson-Nernst-Planck; NERNST-PLANCK; CONDUCTION; TRANSPORT;

D O I：

10.1007/s10955-014-1159-8

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

Ionic currents accompanying DNA translocation strongly depend on molarity of the electrolyte solution and the shape and surface charge of the nanopore. By means of the Poisson-Nernst-Planck equations it is shown how conductance is modulated by the presence of the DNA intruder and as a result of competing electrostatic and confinement factors. The theoretical results reproduce quantitatively the experimental ones and are summarized in a conductance diagram that allows distinguishing the region of reduced conductivity from the region of enhanced conductivity as a function of molarity and the pore dimension.

引用

页码：1181 / 1194

页数：14

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