The role of guggulsterone on the NF-κB pathway in inflammatory bowel disease: preclinical evidence

被引：5
|
作者：
Priya, S. K. Sujitha [1 ]
Jha, Ankita [1 ]
Satish Kumar, Rajappan Chandra [2 ]
Sabarathinam, Sarvesh [2 ]
机构：
[1] SRM Inst Sci & Technol, Dept Pharm Practice, Kancheepuram 603203, Tamil Nadu, India
[2] SRM Inst Sci & Technol, Interdisciplinary Inst Indian Syst Med IIISM, Drug Testing Lab, Kattankulathur 603203, Tamil Nadu, India
来源：
FUTURE SCIENCE OA | 2022年 / 8卷 / 06期
关键词：
bioactive compounds; cytokines; dextran sodium sulfate; guggulsterone; inflammatory bowel disease; intestinal epithelial cells; NF-kappa B; preclinical studies; ulcerative colitis; INTESTINAL EPITHELIAL-CELLS; CYTOKINES; COLITIS;
D O I：
10.2144/fsoa-2022-0020
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Guggulsterone, a phytosterol in the herb Commiphora wightii (Arn.) Bhandari, has been used in the treatment of diseases such as hyperlipidemia, arthritis and atherosclerosis. It has attracted significant research interest because of its pharmacological properties, especially its anti-inflammatory nature. It can be used for the treatment of inflammatory bowel disease (IBD), a disease characterized by chronic inflammation and damage in the gastrointestinal tract. In various preclinical studies, it inhibited NF-kappa B, an important pathway in the pathophysiology of IBD. This review summarizes the preclinical studies on this topic for providing more insights to the mechanism by which guggulsterone exerts its effect.
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页数：5
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