How important are post-translational modifications in p53 for selectivity in target-gene transcription and tumour suppression?

被引:157
作者
Olsson, A.
Manzl, C.
Strasser, A.
Villunger, A. [1 ]
机构
[1] Innsbruck Med Univ, Div Dev Immunol, Bioctr, A-6020 Innsbruck, Austria
[2] Walter & Eliza Hall Inst Med Res, Mol Genet Canc Div, Melbourne, Vic, Australia
基金
奥地利科学基金会;
关键词
p53; apoptosis; cell cycle; tumourigenesis;
D O I
10.1038/sj.cdd.4402196
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A number of elegant studies exploring the consequences of expression of various mutant forms of p53 in mice have been published over the last years. The results and conclusions drawn from these studies often contradict results previously obtained in biochemical assays and cell biology studies, questioning their relevance for p53 function in vivo. Owing to the multitude of post-translational modifications imposed on p53, however, the in vivo validation of their relevance for proper protein function and tumour suppression is constantly lagging behind new biochemical discoveries. Nevertheless, mouse genetics presents again its enormous power. Despite being relatively slow and tedious, it has become indispensable for researchers to sort out the wheat from the chaff in an endless sea of publications on p53.
引用
收藏
页码:1561 / 1575
页数:15
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