THE HISTONE MUTATION H3.3-G34R ENCOUNTERED IN PEDIATRIC HIGH GRADE GLIOMA MODIFIES THE TUMOR IMMUNE MICROENVIRONMENT RENDERING IT MORE PERMISSIVE FOR IMMUNE MEDIATED THERAPIES

被引:0
|
作者
Garcia-Fabiani, Maria B. [1 ]
Kadiyala, Padma [2 ]
Haase, Santiago [1 ]
Alghamri, Mahmoud [1 ]
Comba, Andrea [2 ]
Nunez, Felipe [2 ]
Whalen, Matthew [1 ]
Lowenstein, Pedro [1 ]
Castro, Maria
机构
[1] Univ Michigan, Ann Arbor, MI 48109 USA
[2] Univ Michigan, Sch Med, Dept Neurosurg, Ann Arbor, MI USA
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
PDTM-20
引用
收藏
页码:191 / 191
页数:1
相关论文
共 11 条
  • [1] CHARACTERIZATION OF THE TUMOR IMMUNE MICROENVIRONMENT IN A PEDIATRIC HIGH GRADE GLIOMA MOUSE MODEL HARBORING THE H3.3-G34R MUTATION
    Fabiani, Maria Garcia
    Haase, Santiago
    Kadiyala, Padma
    Alghamri, Mahmoud
    Comba, Andrea
    Nunez, Felipe
    Whalen, Matthew
    Lowenstein, Pedro
    Castro, Maria
    NEURO-ONCOLOGY, 2019, 21 : 121 - 121
  • [2] INVESTIGATING THE ROLE OF OSTEOPONTIN IN RADIORESISTANCE OF H3.3-G34R PEDIATRIC HIGH-GRADE GLIOMA
    Mukherji, Devarshi
    Haase, Santiago
    Varela, Maria Luisa
    Welch, Joshua
    Lowenstein, Pedro
    Castro, Maria
    NEURO-ONCOLOGY, 2024, 26
  • [3] Historadiological correlations in high-grade glioma with the histone 3.3 G34R mutation
    Puntonet, Julien
    Dangouloff-Ros, Volodia
    Saffroy, Raphael
    Pages, Melanie
    Andreiuolo, Felipe
    Grill, Jacques
    Puget, Stephanie
    Boddaert, Nathalie
    Varlet, Pascale
    JOURNAL OF NEURORADIOLOGY, 2018, 45 (05) : 316 - 322
  • [4] CHARACTERIZING THE ROLE H3.3G34R MUTATION IN PEDIATRIC HIGH GRADE ASTROCYTOMA
    Kim, Byungjin
    Siddaway, Robert
    Milos, Scott
    Pajovic, Sanja
    Hawkins, Cynthia
    NEURO-ONCOLOGY, 2019, 21 : 91 - 91
  • [5] ELUCIDATING MOLECULAR PATHOGENIC MECHANISMS OF THE HISTONE H3.3 G34R MUTATION IN PEDIATRIC HIGH-GRADE GLIOMAS (HGGs)
    Haase, Santiago
    Garcia-Fabiani, Maria Belen
    Nunez, Felipe
    Kadiyala, Padma
    Nunez, Fernando
    Lowenstein, Pedro
    Castro, Maria
    NEURO-ONCOLOGY, 2018, 20 : 208 - 208
  • [6] Molecular characterization of a pediatric high-grade glioma (pHGG) mouse model harboring the H3.3 G34R mutation
    Whalen, Matthew J.
    Garcia-Fabiani, Maria B.
    Nunez, Felipe J.
    Lowenstein, Pedro R.
    Castro, Maria G.
    CANCER RESEARCH, 2019, 79 (13)
  • [7] H3.3-G34 mutations impair DNA repair and promote cGAS/STING-mediated immune responses in pediatric high-grade glioma models
    Haase, Santiago
    Banerjee, Kaushik
    Mujeeb, Anzar A.
    Hartlage, Carson S.
    Nunez, Fernando M.
    Nunez, Felipe J.
    Alghamri, Mahmoud S.
    Kadiyala, Padma
    Carney, Stephen
    Barissi, Marcus N.
    Taher, Ayman W.
    Brumley, Emily K.
    Thompson, Sarah
    Dreyer, Justin T.
    Alindogan, Caitlin T.
    Garcia-Fabiani, Maria B.
    Comba, Andrea
    Venneti, Sriram
    Ravikumar, Visweswaran
    Koschmann, Carl
    Carcaboso, Angel M.
    Vinci, Maria
    Rao, Arvind
    Yu, Jennifer S.
    Lowenstein, Pedro R.
    Castro, Maria G.
    JOURNAL OF CLINICAL INVESTIGATION, 2022, 132 (22):
  • [8] HISTONE H3.3 G34R/V MUTATIONS STIMULATE PEDIATRIC HIGH-GRADE GLIOMA FORMATION THROUGH THE INDUCTION OF CHROMOSOMAL INSTABILITY
    Day, Charles
    Grigore, Florina
    Langfald, Alyssa
    Hinchcliffe, Edward
    Robinson, James
    NEURO-ONCOLOGY, 2021, 23 : 29 - 29
  • [9] HISTONE H3.3 G34R/V MUTATIONS STIMULATE PEDIATRIC HIGH-GRADE GLIOMA FORMATION THROUGH THE INDUCTION OF CHROMOSOMAL INSTABILITY
    Grigore, Florina
    Robinson, James
    Langfald, Alyssa
    Hinchcliffe, Edward
    Day, Charles
    NEURO-ONCOLOGY, 2021, 23 : 23 - 23
  • [10] TARGETED DRUGS SYNERGIZE WITH DOUBLE ALKYLATOR THERAPY IN H3.3 G34R/V PEDIATRIC HIGH-GRADE GLIOMA
    Haase, Rebecca
    Green, Adam
    Kilburn, Lindsay
    Filbin, Mariella
    NEURO-ONCOLOGY, 2023, 25