Health-related quality of life and risk factors associated with spirometric restriction

被引:54
作者
Guerra, Stefano [1 ,2 ,3 ,4 ]
Carsin, Anne-Elie [2 ,3 ,4 ,5 ]
Keidel, Dirk [6 ,7 ]
Sunyer, Jordi [2 ,3 ,4 ,5 ]
Leynaert, Benedicte [8 ,9 ]
Janson, Christer [10 ]
Jarvis, Debbie [11 ]
Stolz, Daiana [12 ]
Rothe, Thomas [13 ]
Pons, Marco [14 ]
Turk, Alexander [15 ]
Anto, Josep M. [2 ,3 ,4 ,5 ]
Probst-Hensch, Nicole [6 ,7 ]
机构
[1] Univ Arizona, Asthma & Airway Dis Res Ctr, Tucson, AZ 85724 USA
[2] ISGlobal, Ctr Res Environm Epidemiol CREAL, Barcelona, Spain
[3] Univ Pompeu Fabra, Barcelona, Spain
[4] CIBERESP, Madrid, Spain
[5] IMIM Hosp del Mar Med Res Inst, Barcelona, Spain
[6] Swiss Trop & Publ Hlth Inst, Basel, Switzerland
[7] Univ Basel, Basel, Switzerland
[8] Inserm, Epidemiol Team, UMR 1152, Pathophysiol & Epidemiol Resp Dis, Paris, France
[9] Univ Paris Diderot Paris 7, UMR 1152, Paris, France
[10] Uppsala Univ, Dept Med Sci, Resp Allergy & Sleep Res, Uppsala, Sweden
[11] Imperial Coll London, Natl Heart & Lung Inst, London, England
[12] Univ Hosp Basel, Clin Pulm Med & Resp Cell Res, Basel, Switzerland
[13] Zurcher Rehazentrum, Davos Pl, Davos, Switzerland
[14] Osped Reg Lugano, Sede Civ, Lugano, Switzerland
[15] Zurcher Rehazentren, Faltigberg Wald, Switzerland
关键词
NUTRITION EXAMINATION SURVEY; FORCED EXPIRATORY VOLUME; LUNG-FUNCTION IMPAIRMENT; 1ST NATIONAL-HEALTH; RESPIRATORY SYMPTOMS; VITAL CAPACITY; FOLLOW-UP; METABOLIC SYNDROME; OLDER PERSONS; UNITED-STATES;
D O I
10.1183/13993003.02096-2016
中图分类号
R56 [呼吸系及胸部疾病];
学科分类号
摘要
The restrictive spirometric pattern is associated with a substantial morbidity and mortality burden. We sought to determine to what extent spirometric restriction is associated with impaired quality of life. We used data from two large population-based European cohorts: 6698 European Community Respiratory Health Survey (ECRHS) and 6069 Swiss Cohort Study on Air Pollution and Lung and Heart Diseases in Adults (SAPALDIA) adult participants. The restrictive pattern was defined as forced expiratory volume in 1 s (FEV1)/forced vital capacity (FVC) >= lower limit of normal (LLN) and FVC <LLN; an obstructive pattern was defined as FEV1/FVC <LLN independent of FVC. The Physical Component Summary and Mental Component Summary of quality of life were computed using the Short Form-36 questionnaire. In both cohorts, the restrictive pattern was associated with heavy smoking, being underweight or obese and the coexistence of respiratory symptoms. In univariate analyses, compared with the normal group, both the restrictive and obstructive pattern had significant Physical Component Summary deficits (-2.77 and -2.08, respectively, in ECRHS; -3.25 and -2.14, respectively, in SAPALDIA; all p-values <0.001). However, in models adjusted for sex, age, education, body mass index, smoking, comorbidities and respiratory symptoms, only the restrictive pattern remained significantly associated with Physical Component Summary deficits (p=0.004 in ECRHS; p=0.001 in SAPALDIA). The restrictive spirometric pattern is associated with deficits in the physical component of quality of life that are partly independent of the presence of respiratory symptoms.
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页数:11
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