Isolation and characterization of a novel clade of coxsackievirus B2 associated with hand, foot, and mouth disease in Southwest China

被引：8

作者：

Zhang, Ming ^{[1
,2
]}

Xu, Danhan ^{[1
,2
]}

Feng, Changzeng ^{[1
,2
]}

Guo, Wei ^{[1
,2
]}

Fei, Chengrui ^{[1
,2
]}

Sun, Hao ^{[1
,2
]}

Yang, Zhaoqing ^{[1
,2
]}

Ma, Shaohui ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biol, Dept Med Genet, 935 Jiao Ling Rd, Kunming 650118, Yunnan, Peoples R China

[2] Chinese Acad Med Sci, Inst Med Biol, Yunnan Key Lab Vaccine Res Dev Severe Infect Dis, Kunming, Yunnan, Peoples R China

来源：

JOURNAL OF MEDICAL VIROLOGY | 2022年 / 94卷 / 06期

关键词：

complete genome; coxsackievirus B2; phylogenetic analysis; temperature sensitivity; virus recombination; ASEPTIC-MENINGITIS; YUNNAN PROVINCE; ENTEROVIRUS; 71; POLIOVIRUS; STRAIN; RECOMBINATION; ADENOVIRUSES; REPLICATION; MYOCARDITIS; INFECTION;

D O I：

10.1002/jmv.27657

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Coxsackievirus B2 (CVB2) is an enterovirus B (EV-B) species and can cause aseptic meningitis, myocarditis and hand, foot, and mouth disease (HFMD). We characterized a novel CVB2 (YN31V3) associated with HFMD in Yunnan, Southwest China, in 2019. Although YN31V3 and other Mainland China epidemic strains mainly belonged to genotype C, YN31V3 formed an independent branch. The genome sequence of the strain YN31V3 from this study showed a 12.91% nucleotide difference to its closest strain RW41-2/YN/CHN/2012. Recombination analyses showed that the newly isolated YN31V3 was probably a recombinant, which was closely related to CVB2 strains in the genomic P1 region and other EV-B strains in the P2 and P3 regions, respectively. YN31V3 strain had a temperature-sensitive phenotype. The challenge of suckling BALB/c mice with YN31V3 could cause symptoms of disease and severe pathological lesions.

引用

页码：2598 / 2606

页数：9

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