Multiparametric quantitative MRI for the evaluation of dysthyroid optic neuropathy

被引:17
作者
Zou, Mengsha [1 ]
Wu, Dide [2 ]
Zhu, Hongzhang [1 ]
Huang, Xiahua [1 ]
Zhao, Xiaojuan [2 ]
Zhao, Jing [1 ]
Fu, Wenhao [1 ]
Li, Ruocheng [1 ]
Li, Bin [3 ]
Wan, Pengxia [4 ]
Hong, Shubin [2 ]
Li, Yanbing [2 ]
Xiao, Haipeng [2 ]
Yang, Zhiyun [1 ]
机构
[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Radiol, 58 Zhongshan Rd 2nd, Guangzhou 510080, Peoples R China
[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Endocrinol, 58 Zhongshan Rd 2nd, Guangzhou 510080, Peoples R China
[3] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Clin Trials Unit, 58 Zhongshan Rd 2nd, Guangzhou 510080, Peoples R China
[4] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Ophthalmol, 58 Zhongshan Rd 2nd, Guangzhou 510080, Peoples R China
基金
中国国家自然科学基金;
关键词
Optic neuropathy; Graves orbitopathy; Dysthyroid optic neuropathy; Magnetic resonance imaging; Muscle index; GRAVES OPHTHALMOPATHY; NERVE; DIAGNOSIS; ORBITOPATHY; DYSFUNCTION; DISEASE; CT;
D O I
10.1007/s00330-021-08300-2
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Objective To evaluate the ability of quantitative MRI parameters for predicting dysthyroid optic neuropathy (DON). Methods We retrospectively collected and analyzed the clinical features and 3.0 T MRI data of 59 patients with Graves orbitopathy (GO), with (n = 26) and without DON (n = 33). We compared MRI quantitative parameters, including the modified muscle index (mMI), proptosis, volume of intra-orbital fat, mean apparent diffusion coefficient value, and T2 value of the optic nerve among patients with and without DON. A logistic regression analysis was performed to identify the risk factors associated with DON. Moreover, we performed a receiver operating characteristic curve analysis and decision curve analysis to evaluate the diagnostic performance of the identified parameters for DON. Results We studied 118 orbits (43 and 75 with and without DON, respectively). The mMI and mean T2 value of the optic nerve were significantly greater in orbits with DON (p < 0.001). A greater mMI at 21 mm (odds ratio (OR), 1.039; 95% confidence interval (CI): 1.019, 1.058) and higher mean T2 value of the optic nerve (OR, 1.035; 95% CI: 1.017, 1.054) were associated with a higher risk of DON. A model combining the mMI at 21 mm and mean T2 values for the optic nerve effectively predicted DON in patients with GO, with a sensitivity and specificity of 95.3% and 76%, respectively. Conclusion A quantitative MRI parameter combining the mMI at 21 mm and mean T2 value of the optic nerve can be an effective imaging marker for identifying DON.
引用
收藏
页码:1931 / 1938
页数:8
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