The synthesis of hybrids of D-galactose with 1-deoxynojirimycin analogues as glycosidase inhibitors

被引：96

作者：

Reddy, BG ^{[1
]}

Vankar, YD ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2005年 / 44卷 / 13期

关键词：

carbohydrates; enzymes; inhibitors; metathesis; ring closure;

D O I：

10.1002/anie.200462413

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Sweet stop: Sugar-azasugar hybrids as enzyme inhibitors and leads for drug discovery are presented. Three hybrids 3 of D-galactose with analogues of 1-deoxynojirimycin were prepared from 3,4,6-tri-O-benzyl-2-nitro-D-galactal (1) by using ring-closing metathesis as a key reaction (see scheme); Bn = benyzl, Boc = tert-butoxycarbonyl, n = 0,1, R = Ac/Boc, R1 = H/OAc, R2 = H/OAc, R3 = H/OAc, R4 = H/OAc. © 2005 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：2001 / 2004

页数：4

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