Double-Strand Breaks on a Genomic DNA Caused by Ultrasound: Evaluation by Single DNA Observation

被引：0

作者：

Kenmotmsu, Takahiro ^{[1
]}

Ogawa, Naoki ^{[1
]}

Kubota, Rinko ^{[1
]}

Yoshida, Kenji ^{[3
]}

Kagawa, Yukihiro ^{[1
]}

Watanabe, Yoshiaki ^{[1
]}

Yoshikawa, Yuko ^{[2
]}

Yoshikawa, Kenich ^{[1
]}

机构：

[1] Doshisha Univ, Fac Life & Med Sci, Kyotanabe, Kyoto 6100394, Japan

[2] Ritsuimeikan Univ, Res Org Sci & Technol, Lab Environm Biotechnol, Shiga 5258577, Japan

[3] Chiba Univ, Res Ctr Frontier Med Engn, Chiba 2638522, Japan

来源：

2013 INTERNATIONAL SYMPOSIUM ON MICRO-NANOMECHATRONICS AND HUMAN SCIENCE (MHS) | 2013年

关键词：

MOLECULE OBSERVATION; COMET ASSAY; IN-VITRO; KINETICS; DAMAGE; CELLS;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Double-strand brakes of T4-DNA molecules caused by ultrasound irradiation are monitored through the methodology of single giant DNA observation by fluorescence microscopy. The experimental results indicate the existence of the threshold power of ultrasound on the double-strand brakes. In addition, we have examined the effect of an anti-oxidative agent, 2-mercaptoethanol (2-Me), on the ultrasound damage of DNA. It becomes clear that 2-Me exhibits almost no protective effect.

引用

页数：3

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