RIP3: a Possible Trigger of Apoptosis or Necrosis

被引：0
作者：
Xu Yang
Zhao Xiao-Hang [1 ]
机构：
[1] Chinese Acad Med Sci, State Key Lab Mol Oncol, Canc Inst & Hosp, Beijing 100021, Peoples R China
来源：
PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS | 2010年 / 37卷 / 10期
基金：
中国国家自然科学基金;
关键词：
RIP3; apoptosis; necrotosis; NF-KAPPA-B; INTERACTING PROTEIN-3 RIP3; CELL-DEATH; TNF-ALPHA; NUCLEAR EXPORT; KINASE; ACTIVATION; IDENTIFICATION; SIGNAL; PHOSPHORYLATION;
D O I：
10.3724/SP.J.1206.2010.00177
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The receptor-interacting protein 3 (RIP3) is a member of RIP kinase family, which has highly conserved serine/threonine kinase activity. Increasing number of evidences has revealed RIPs to be essential sensors of cellular stress and a key regulator of cell apoptosis, necrosis and survival. Recent studies demonstrating RIP3 as a possible trigger for cellular necrosis in response to TNF-alpha family of death inducing cytokines may lead to new strategies for developing cancer therapy. This review focuses on the biological characteristics and structure of RIP3 protein, and its cell death control function between apoptotic and necrotic.
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收藏
页码：1067 / 1073
页数：7
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