Copper-Catalyzed Carbonylative Coupling of Cycloalkanes and Amides

被引：79

作者：

Li, Yahui ^{[1
]}

Dong, Kaiwu ^{[1
]}

Zhu, Fengxiang ^{[1
]}

Wang, Zechao ^{[1
]}

Wu, Xiao-Feng ^{[1
,2
]}

机构：

[1] Univ Rostock, Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany

[2] Zhejiang Sci Tech Univ, Dept Chem, Xiasha Campus, Hangzhou 310018, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 25期

关键词：

amides; carbonylation; copper catalysis; cycloalkanes; imides; C-H ACTIVATION; OXIDATIVE CARBONYLATION; C(SP(3))-H BONDS; REGIOSELECTIVE CARBONYLATION; ANILINES; AMINOCARBONYLATION; CONSTRUCTION; HETEROCYCLES; C(SP(2))-H; RUTHENIUM;

D O I：

10.1002/anie.201603235

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carbonylation reactions are a most powerful method for the synthesis of carbonyl-containing compounds. However, most known carbonylation procedures still require noble-metal catalysts and the use of activated compounds and good nucleophiles as substrates. Herein, we developed a copper-catalyzed carbonylative transformation of cycloalkanes and amides. Imides were prepared in good yields by carbonylation of a C(sp(3))-H bond of the cycloalkane with the amides acting as weak nucleophiles. Notably, this is the first report of copper-catalyzed carbonylative C-H activation.

引用

页码：7227 / 7230

页数：4

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