Engineering Tools for the Development of Recombinant Lactic Acid Bacteria

被引：30
作者：
Cho, Sung Won [1 ]
Yim, Jaewoo [1 ]
Seo, Sang Woo [1 ]
机构：
[1] Seoul Natl Univ, Inst Chem Proc, Sch Chem & Biol Engn, 1 Gwanak Ro, Seoul 08826, South Korea
来源：
BIOTECHNOLOGY JOURNAL | 2020年 / 15卷 / 06期
基金：
新加坡国家研究基金会;
关键词：
genetic engineering; lactic acid bacteria; synthetic biology; CONTROLLED GENE-EXPRESSION; LACTOCOCCUS-LACTIS; LACTOBACILLUS-PLANTARUM; CLONING VECTORS; TECHNICAL CONDITIONS; REPLICATION REGION; BACILLUS-SUBTILIS; ORAL IMMUNIZATION; MUCOSAL DELIVERY; SIGNAL PEPTIDES;
D O I：
10.1002/biot.201900344
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Lactic acid bacteria (LAB) is mainly used in food fermentation. In addition, LAB fermentation technology has been studied in the development of industrial food additives, nutrients, or enzymes used in food processing. In the field of red biotechnology, LAB is approved and is generally recognized as a safe organism and is considered safe for biotherapeutic treatments. Recent clinical trials have demonstrated the medicinal value of therapeutic recombinant LAB and the suitability of innate mechanisms of secretion and anchoring for therapeutic applications such as antibody or vaccine production. However, the gram-positive phenotypic trait of LAB creates challenges for genetic modifications when compared to other conventional workhorse bacteria, resulting in exclusive developments of genetic tools for engineering LAB. In this review, several distinct approaches in gene expression for engineering LAB are discussed.
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页数：10
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