Encapsulation of Pharmaceutical and Nutraceutical Active Ingredients Using Electrospinning Processes

被引：71
作者：
Zare, Mina [1 ,2 ]
Dziemidowicz, Karolina [2 ]
Williams, Gareth R. [2 ]
Ramakrishna, Seeram [1 ]
机构：
[1] Natl Univ Singapore, Ctr Nanotechnol & Sustainabil, Singapore 117581, Singapore
[2] UCL, UCL Sch Pharm, 29-39 Brunswick Sq, London WC1N 1AX, England
来源：
NANOMATERIALS | 2021年 / 11卷 / 08期
关键词：
electrospinning; encapsulation; nanocarrier; nanofiber; nutraceuticals; probiotics; target drug delivery; DRUG-DELIVERY SYSTEMS; BLOCK-COPOLYMER MICELLES; CONTROLLED-RELEASE; POLYMERIC NANOPARTICLES; CORE/SHELL NANOFIBERS; PROBIOTIC BACTERIA; FIBERS; MECHANISMS; DESIGN; PROGRESS;
D O I：
10.3390/nano11081968
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
Electrospinning is an inexpensive and powerful method that employs a polymer solution and strong electric field to produce nanofibers. These can be applied in diverse biological and medical applications. Due to their large surface area, controllable surface functionalization and properties, and typically high biocompatibility electrospun nanofibers are recognized as promising materials for the manufacturing of drug delivery systems. Electrospinning offers the potential to formulate poorly soluble drugs as amorphous solid dispersions to improve solubility, bioavailability and targeting of drug release. It is also a successful strategy for the encapsulation of nutraceuticals. This review aims to briefly discuss the concept of electrospinning and recent progress in manufacturing electrospun drug delivery systems. It will further consider in detail the encapsulation of nutraceuticals, particularly probiotics.
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页数：15
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