Meiosis: the chromosomal foundation of reproduction

被引：116

作者：

Bolcun-Filas, Ewelina ^{[1
]}

Handel, Mary Ann ^{[1
]}

机构：

[1] Jackson Lab, 600 Main St, Bar Harbor, ME 04609 USA

来源：

BIOLOGY OF REPRODUCTION | 2018年 / 99卷 / 01期

关键词：

meiosis; gametogenesis; chromosomes; reproduction; MAMMALIAN SYNAPTONEMAL COMPLEX; HUMAN FEMALE MEIOSIS; DOUBLE-STRAND BREAKS; TRANSMISSION RATIO DISTORTION; MOUSE COLLABORATIVE CROSS; AGE-RELATED ALTERATIONS; MEIOTIC PROPHASE-I; GERM-CELLS; XY BODY; DROSOPHILA-MELANOGASTER;

D O I：

10.1093/biolre/ioy021

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Meiosis is the chromosomal foundation of reproduction, with errors in this important process leading to aneuploidy and/or infertility. In this review celebrating the 50th anniversary of the founding of the Society for the Study of Reproduction, the important chromosomal structures and dynamics contributing to genomic integrity across generations are highlighted. Critical unsolved biological problems are identified, and the advances that will lead to their ultimate resolution are predicted. Summary Sentence The chromosomal dynamics that underlie meiosis, the defining event of gametogenesis, are reviewed, with a look forward to advances that are on the horizon.

引用

页码：112 / 126

页数：15

共 203 条

[1] Revolutionizing male fertility factor research in mice by using the genome editing tool CRISPR/Cas9 [J].

Abbasi, Ferheen ;

Miyata, Haruhiko ;

Ikawa, Masahito .

REPRODUCTIVE MEDICINE AND BIOLOGY, 2018, 17 (01) :3-10

[2] Spindle asymmetry drives non-Mendelian chromosome segregation [J].

Akera, Takashi ;

Chmatal, Lukas ;

Trimm, Emily ;

Yang, Karren ;

Aonbangkhen, Chanat ;

Chenoweth, David M. ;

Janke, Carsten ;

Schultz, Richard M. ;

Lampson, Michael A. .

SCIENCE, 2017, 358 (6363) :668-+

[3]

Alsheimer M., 2009, V5, P81, DOI 10.1159/000166621

[4] The mouse "tool box" for meiotic studies [J].

Ashley, T .

CYTOGENETIC AND GENOME RESEARCH, 2004, 105 (2-4) :166-171

[5] Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome [J].

Baarends, Willy M. ;

Wassenaar, Evelyne ;

Hoogerbrugge, Jos W. ;

Schoenmakers, Sam ;

Sun, Zu-Wen ;

Grootegoed, J. Anton .

JOURNAL OF CELL SCIENCE, 2007, 120 (11) :1841-1851

[6] Regulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes [J].

Ball, Robyn L. ;

Fujiwara, Yasuhiro ;

Sun, Fengyun ;

Hu, Jianjun ;

Hibbs, Matthew A. ;

Handel, Mary Ann ;

Carter, Gregory W. .

BMC GENOMICS, 2016, 17

[7] Telomere dynamics unique to meiotic prophase: formation and significance of the bouquet [J].

Bass, HW .

CELLULAR AND MOLECULAR LIFE SCIENCES, 2003, 60 (11) :2319-2324

[8] Chromosome synapsis defects and sexually dimorphic meiotic progression in mice lacking Spo11 [J].

Baudat, F ;

Manova, K ;

Yuen, JP ;

Jasin, M ;

Keeney, S .

MOLECULAR CELL, 2000, 6 (05) :989-998

[9] Genetic Interference: Don't Stand So Close to Me [J].

Berchowitz, Luke E. ;

Copenhaver, Gregory P. .

CURRENT GENOMICS, 2010, 11 (02) :91-102

[10] Distinct Roles of Meiosis-Specific Cohesin Complexes in Mammalian Spermatogenesis [J].

Biswas, Uddipta ;

Hempel, Kai ;

Llano, Elena ;

Pendas, Alberto ;

Jessberger, Rolf .

PLOS GENETICS, 2016, 12 (10)

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