Synthesis of Biocompatible and Thermally Sensitive Poly(N-vinylcaprolactam) Nanogels via Inverse Miniemulsion Polymerization: Effect of the Surfactant Concentration

被引：42

作者：

Medeiros, Simone F. ^{[3
]}

Santos, Amilton M. ^{[3
]}

Fessi, Hatem ^{[1
,2
]}

Elaissari, Abdelhamid ^{[1
,2
]}

机构：

[1] Univ Lyon 1, Lab Automat & Ge Nie Procedes, F-69622 Villeurbanne, France

[2] CNRS, UMR 5007, Lyon, France

[3] Univ Sao Paulo, Escola Engn Quim Lorena, Dept Engn Quim, Lab Polimeros, BR-12602810 Lorena, SP, Brazil

来源：

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY | 2010年 / 48卷 / 18期

关键词：

biocompatible; biodegradable; hydrophilic polymers; inverse miniemulsion polymerization; LCST; microgels; radical polymerization; stimuli-responsive polymers; stimuli-sensitive polymers; surfactant; PHASE-BEHAVIOR; PARTICLES; POLY(N-ISOPROPYLACRYLAMIDE); ROUTE; MICROEMULSION; MICROSPHERES; EMULSIONS; RELEASE; SYSTEM;

D O I：

10.1002/pola.24165

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The goal of this study was to develop a new route to prepare thermally responsive polymer nanogels Poly (N-vinylcaprolactam) nanogels were prepared via inverse miniemulsion polymerization (MO) at 70 degrees C using n-hexadecane as a nonpolar continuous phase, potassium persulfate as an initiator, and N,N'-methylenebisacrylamide as a crosslinker. Sorbitan monooleate (Span 80) was used as surfactant and its influence on the polymerization kinetics and on the colloidal characteristics of the nanogels were principally investigated It was observed that the addition of a strong "lipophobe" is required to stabilize the resulting miniemulsion The nanogels were characterized in terms of morphology, size, zeta potential, and thermoproperties using transmission electron microscopy and dynamic light scattering It was observed that all the nanogels obtained collapsed when the lower critical solution temperature (LCST) was raised (C) 2010 Wiley Periodicals, Inc J Polym Sci Part A Polym Chem 48 3932-3941, 2010

引用

页码：3932 / 3941

页数：10

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