Severe Abdominal Recurrence of Low-grade Endometrial Stromal Sarcoma After Hysteroscopic Surgery

被引：3

作者：

Tamura, Daisuke ^{[1
,2
]}

Maeda, Daichi ^{[3
,4
]}

Enomoto, Katsuhiko ^{[5
]}

Sato, Hirokazu ^{[1
]}

机构：

[1] Akita Red Cross Hosp, Dept Gynecol, Akita, Japan

[2] Akita Univ, Grad Sch Med, Dept Obstet & Gynecol, 1-1-1 Hondo, Akita, Akita 0108543, Japan

[3] Osaka Univ, Grad Sch Med, Dept Clin Gen, Osaka, Japan

[4] Kanazawa Univ, Grad Sch Med Sci, Dept Mol & Cellular Pathol, Kanazawa, Ishikawa, Japan

[5] Akita Red Cross Akita Hosp, Dept Pathol, Akita, Japan

来源：

ANTICANCER RESEARCH | 2021年 / 41卷 / 08期

关键词：

Low-grade endometrial stromal sarcoma; JAZF1-SUZ12; hysteroscopic surgery;

D O I：

10.21873/anticanres.15199

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Low-grade endometrial stromal sarcoma (LG-ESS) is an indolent tumor harboring gene fusion involving polycomb family genes. While early LG-ESS has a good clinical course, some tumors have pelvic recurrence. The etiology and genetic alterations involved in the process remain unknown. Case Report: A 44-year-old nulliparous woman underwent hysteroscopic surgery for a 2.5 cm submucosal uterine tumor with negative endometrial cytology. Pathological evaluation revealed LG-ESS. On the 31st day, total laparoscopic hysterectomy was indicated. She was diagnosed with stage IA (pT1aNXM0) LG-ESS without lymphovascular invasion. At 4 years, positron-emission tomography showed multiple pelvic masses. Secondary debulking surgery was performed, which revealed severe intra-abdominal recurrence of LG-ESS with JAZF1-SUZ12 fusion. Conclusion: Hysteroscopic surgery is a convenient tool for benign uterine submucosal diseases. However, intrauterine morcellation with fluid can lead to unexpected recurrence of occult LG-ESS. It is important when seeking consent for surgery to inform patients about the possible risk of dissemination of uterine mesenchymal tumors.

引用

页码：4013 / 4016

页数：4

共 14 条

[1] The Use of Hysteroscopy for the Diagnosis and Treatment of Intrauterine Pathology ACOG Committee Opinion, Number 800 [J].