STEREOSELECTIVE FORMAL TOTAL SYNTHESIS OF NOVEL ANTIBIOTIC (-)-CENTROLOBINE

被引：17

作者：

Mohapatra, Debendra K. ^{[1
]}

Pal, Rita ^{[1
]}

Rahaman, Hasibur ^{[1
]}

Gurjar, Mukund K. ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

HETEROCYCLES | 2010年 / 80卷 / 01期

关键词：

Centrolobine; Antibiotic; Sharpless Asymmetric Epoxidation; Ring-Closing Metathesis; Keck Allylation; DOUBLE INTRAMOLECULAR OXYMERCURATION; NATURAL-PRODUCTS; CIS-2,6-DISUBSTITUTED TETRAHYDROPYRANS; ALPINIA-BLEPHAROCALYX; PRINS CYCLIZATIONS; (+/-)-CENTROLOBINE; DIARYLHEPTANOIDS; TETRAHYDROFURAN; EPIMERIZATION; SUPPRESSION;

D O I：

10.3987/COM-08-S(S)1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A concise and stereoselective formal total synthesis of (-)-centrolobine is achieved utilizing Mioskowski's Lewis acid mediated epoxide opening followed by ring-closing metathesis as the key reaction.

引用

页码：219 / 227

页数：9

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