Applications of Patient-Specific Induced Pluripotent Stem Cells; Focused on Disease Modeling, Drug Screening and Therapeutic Potentials for Liver Disease

被引：0
作者：
Chun, Yong Soon [1 ]
Chaudhari, Pooja [1 ]
Jang, Yoon-Young [1 ]
机构：
[1] Johns Hopkins Univ, Sch Med, Stem Cell Biol Lab, Dept Oncol, Baltimore, MD 21231 USA
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES | 2010年 / 6卷 / 07期
关键词：
Stem Cell; Disease Modeling; Drug Screening; Liver Disease; HEPATOCELLULAR-CARCINOMA; DEFINED FACTORS; GENERATION; MOUSE; INDUCTION; EFFICIENT; DIFFERENTIATION; ANEMIA; HEPATOCYTES; FIBROBLASTS;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The recent advances in the induced pluripotent stem cell (iPSC) research have significantly changed our perspectives on regenerative medicine by providing researchers with a unique tool to derive disease s-pecific stem cells for study. In this review, we describe the human iPSC generation from developmentally diverse origins (i.e. endoderm-, mesoderm-, and ectoderm-tissue derived human iPSCs) and multistage hepatic differentiation protocols, and discuss both basic and clinical applications of these cells including disease modeling, drug toxicity screening/drug discovery, gene therapy and cell replacement therapy.
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收藏
页码：796 / 805
页数：10
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