Evidence for Reduced Long-Term Potentiation-Like Visual Cortical Plasticity in Schizophrenia and Bipolar Disorder

被引：19

作者：

Valstad, Mathias ^{[1
,2
]}

Roelfs, Daniel ^{[1
,2
]}

Slapo, Nora B. ^{[1
,2
]}

Timpe, Clara M. F. ^{[1
,2
,3
]}

Rai, Ahsan ^{[4
]}

Matziorinis, Anna Maria ^{[5
]}

Beck, Dani ^{[1
,2
,3
]}

Richard, Genevieve ^{[1
,2
]}

Saether, Linn Sofie ^{[1
,2
]}

Haatveit, Beathe ^{[1
,2
]}

Nordvik, Jan Egil ^{[6
]}

Hatlestad-Hall, Christoffer ^{[3
,7
]}

Einevoll, Gaute T. ^{[8
,9
]}

Maki-Marttunen, Tuomo ^{[1
,2
,10
]}

Haram, Marit ^{[1
,2
]}

Ueland, Torill ^{[1
,2
,3
]}

Lagerberg, Trine, V ^{[1
,2
]}

Steen, Nils Eiel ^{[1
,2
]}

Melle, Ingrid ^{[1
,2
]}

Westlye, Lars T. ^{[1
,2
,3
]}

Jonsson, Erik G. ^{[1
,2
,11
,12
]}

Andreassen, Ole A. ^{[1
,2
]}

Moberget, Torgeir ^{[1
,2
,3
]}

Elvsashagen, Torbjorn ^{[1
,2
,7
]}

机构：

[1] Univ Oslo, Oslo Univ Hosp, Div Mental Hlth & Addict, NORMENT, Oslo, Norway

[2] Univ Oslo, Inst Clin Med, Oslo, Norway

[3] Univ Oslo, Dept Psychol, Oslo, Norway

[4] Hosp Sick Children, Div Plast & Reconstruct Surg, Toronto, ON, Canada

[5] Univ Bergen, Fac Psychol, Bergen, Norway

[6] CatoSenteret Rehabil Ctr, Son, Norway

[7] Oslo Univ Hosp, Dept Neurol, Oslo, Norway

[8] Norwegian Univ Life Sci, Fac Sci & Technol, As, Norway

[9] Univ Oslo, Dept Phys, Oslo, Norway

[10] Simula Res Lab, Oslo, Norway

[11] Karolinska Inst, Ctr Psychiat Res, Dept Clin Neurosci, Stockholm, Sweden

[12] Stockholm Cty Council, Stockholm Hlth Care Sci, Stockholm, Sweden

来源：

SCHIZOPHRENIA BULLETIN | 2021年 / 47卷 / 06期

关键词：

synaptic plasticity; EEG; visual evoked potentials; psychosis; mood states; psychotropic medication; COGNITIVE IMPAIRMENT; SYNAPTIC PLASTICITY; EVOKED-POTENTIALS; KETAMINE; HUMANS; SCALE; PREVALENCE; EXPERIENCE; MODEL; RISK;

D O I：

10.1093/schbul/sbab049

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Several lines of research suggest that impairments in long-term potentiation (LTP)-like synaptic plasticity might be a key pathophysiological mechanism in schizophrenia (SZ) and bipolar disorder type I (BDI) and II (BDII). Using modulations of visually evoked potentials (VEP) of the electroencephalogram, impaired LTP-like visual cortical plasticity has been implicated in patients with BDII, while there has been conflicting evidence in SZ, a lack of research in BDI, and mixed results regarding associations with symptom severity, mood states, and medication. We measured the VEP of patients with SZ spectrum disorders (n = 31), BDI (n = 34), BDII (n = 33), and other BD spectrum disorders (n = 2), and age-matched healthy control (HC) participants (n = 200) before and after prolonged visual stimulation. Compared to HCs, modulation of VEP component N1b, but not C1 or P1, was impaired both in patients within the SZ spectrum (chi(2) = 35.1, P = 3.1 x 10(-9)) and BD spectrum (chi(2) = 7.0, P = 8.2 x 10(-3)), including BDI (chi(2) = 6.4, P = .012), but not BDII (chi(2) = 2.2, P = .14). N1b modulation was also more severely impaired in SZ spectrum than BD spectrum patients (chi(2) = 14.2, P = 1.7 x 10(-4)). N1b modulation was not significantly associated with Positive and Negative Syndrome Scale (PANSS) negative or positive symptoms scores, number of psychotic episodes, Montgomery and angstrom sberg Depression Rating Scale (MADRS) scores, or Young Mania Rating Scale (YMRS) scores after multiple comparison correction, although a nominal association was observed between N1b modulation and PANSS negative symptoms scores among SZ spectrum patients. These results suggest that LTP-like plasticity is impaired in SZ and BD. Adding to previous genetic, pharmacological, and electrophysiological evidence, these results implicate aberrant synaptic plasticity as a mechanism underlying SZ and BD.

引用

页码：1751 / 1760

页数：10

共 50 条

[1] The role of L-type voltage-gated calcium channels Cav1.2 and Cav1.3 in normal and pathological brain function [J].