Isolation of Anaerobic Bacteria During Quality Analysis of Medicinal Products

被引：1

作者：

Sakhno, N. G. ^{[1
]}

Gunar, O. V. ^{[1
]}

Roshchina, M. V. ^{[1
]}

Kolosova, L. V. ^{[1
]}

Grigor'eva, V. E. ^{[1
]}

机构：

[1] Minist Hlth Russian Federat, Sci Ctr Expert Evaluat Med Prod, 8-2 Petrovskii Blvd, Moscow 127051, Russia

来源：

PHARMACEUTICAL CHEMISTRY JOURNAL | 2018年 / 52卷 / 06期

关键词：

medicinal products; anaerobic microorganisms; sterility testing; AUTOMATED CULTURE-SYSTEMS; STEM-CELL PRODUCTS; MICROBIAL-CONTAMINATION; HEMATOPOIETIC PROGENITOR; TRANSPLANT;

D O I：

10.1007/s11094-018-1861-y

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Important features of the isolation of anaerobic microorganisms were examined. The detection limit and frequency and time for isolating several anaerobic bacteria by direct inoculation on thioglycollate medium and by a BacT/ALERT 3D automated system were established. Isolation of individual cells of anaerobic microorganisms with different tolerances to oxygen was shown to be possible by using thioglycollate growth medium to analyze the sterility of medicinal products. The minimum number of cells in a sample could be reliably determined in less time by using a BacT/ALERT 3D automated system and special growth medium.

引用

页码：569 / 572

页数：4

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