Chiral separation of sympathomimetics and β-blockers by ligand-exchange CE using Cu(II) complexes of L-tartaric acid and L-threonine as chiral selectors

被引：36

作者：

Hoedl, Heike ^{[1
]}

Krainer, Axel ^{[1
]}

Holzmueller, Katja ^{[1
]}

Koidl, Julia ^{[1
]}

Schmid, Martin G. ^{[1
]}

Guebitz, Gerald ^{[1
]}

机构：

[1] Karl Franzens Univ Graz, Inst Pharmaceut Sci, Dept Pharmaceut Chem, A-8010 Graz, Austria

来源：

ELECTROPHORESIS | 2007年 / 28卷 / 15期

关键词：

CE; enantiomer separation; ligand exchange; sympathomimetics; beta-blockers;

D O I：

10.1002/elps.200600825

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

This paper deals with the use of Cu(II) complexes Of L-tartaric acid or L-threonine as selectors for the chiral separation of drugs containing amino alcohol structure by ligand-exchange CE. Using Cu(II) ions as a complexing agent, a series of sympathomimetics and beta-blockers were resolved. It was found that the resolution strongly depends on selector concentration and pH. The optimum pH for complexation was 12.

引用

页码：2675 / 2682

页数：8

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