3D printing of hydroxyapatite polymer-based composites for bone tissue engineering

被引：69

作者：

Corcione, Carola Esposito ^{[1
]}

Gervaso, Francesca ^{[1
]}

Scalera, Francesca ^{[1
]}

Montagna, Francesco ^{[1
]}

Maiullaro, Tommaso ^{[1
]}

Sannino, Alessandro ^{[1
]}

Maffezzoli, Alfonso ^{[1
]}

机构：

[1] Univ Salento, Dipartimento Ingn Innovaz, Via Monteroni, I-73100 Lecce, Italy

来源：

JOURNAL OF POLYMER ENGINEERING | 2017年 / 37卷 / 08期

关键词：

biomaterials; 3D printing; hydroxyapatite; PLA; BMP-INDUCED OSTEOGENESIS; FREE-FORM FABRICATION; ZRO2 TOUGHENED AL2O3; EPOXY-BASED RESIN; MECHANICAL-PROPERTIES; PHOTOPOLYMERIZATION KINETICS; LASER STEREOLITHOGRAPHY; POROUS HYDROXYAPATITE; SCAFFOLDS; BIOCOMPATIBILITY;

D O I：

10.1515/polyeng-2016-0194

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Skeletal defects reconstruction, using custommade substitutes, represents a valid solution to replacing lost and damaged anatomical bone structures, renew their original function, and at the same time, restore the original aesthetic aspect. Rapid prototyping (RP) techniques allow the construction of complex physical models based on 3D clinical images. However, RP machines usually work with synthetic polymers; therefore, producing custom-made scaffolds using a biocompatible material directly by RP is an exciting challenge. The aim of the present work is to investigate the potentiality of 3D printing as a manufacturing method to produce an osteogenic hydroxyapatite polylactic acid bone graft substitute.

引用

页码：741 / 746

页数：6

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[21] Effect of bioactive extruded PLA/HA composite films on focal adhesion formation of preosteoblastic cells [J].