Synthesis, characterization, structures and cytotoxicity of platinum(II) complexes containing dimethylpyrazole based selenium ligands

被引：17
作者：
Chopade, Suresh M. [1 ]
Phadnis, Prasad P. [1 ]
Hodage, Ananda S. [1 ]
Wadawale, Amey [1 ]
Jain, Vimal K. [1 ]
机构：
[1] Bhabha Atom Res Ctr, Div Chem, Bombay 400085, Maharashtra, India
来源：
INORGANICA CHIMICA ACTA | 2015年 / 427卷
关键词：
Platinum; Selenium; Dimethylpyrazole; X-ray structure; Cytotoxicity; DNA PLATINATION; GLUTATHIONE; PALLADIUM(II); METHIONINE; REACTIVITY; SULFUR; TETRAHYDROFURAN; CISPLATIN; ADDUCTS; TARGET;
D O I：
10.1016/j.ica.2014.11.017
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
A series of water soluble platinum(II) complexes of general formulae [Pt(en)(L)][NO3](2), [Pt(NH3)(2) (L)][NO3](2) [en = ethylenediamine; L = dmpzC(6)H(4)Se(CH2)(n)COOH or dmpzCH(2)CH(2)Se(CH2)(n)COOH (n = 1 and 2)], [Pt(en)(L)][NO3][OH]center dot H2O [L = dmpzCH(2)CH(2)Se(CH2)(n)COOH (n = 1 and 2)] and [Pt(dmpzCH(2)CH(2) SeCH2CH2COOH)(2)][Cl](2)center dot 2H(2)O have been synthesized. They were characterized by microanalyses, IR, NMR (H-1, C-13{H-1}, Se-77{H-1} and Pt-195{H-1}) spectroscopy. Molecular structures of [Pt(en)(dmpzCH(2)CH(2) SeCH2COOH)][NO3][OH]center dot H2O and [Pt(dmpzCH(2)CH(2)SeCH(2)CH(2)COOH)(2)][Cl](2)center dot 2H(2)O were determined unambiguously by single crystal X-ray diffraction analyses. The cytotoxicity of these complexes has been evaluated against human colon (HT29, Colo205), ovarian (A2780) and bladder (T24) cancer cell lines and compared with the activity of cisplatin and adriamycin. (C) 2014 Elsevier B.V. All rights reserved.
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页码：72 / 80
页数：9
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