Brownian motion in a modulated optical trap

被引：40

作者：

Deng, Yi ^{[1
]}

Bechhoefer, John ^{[1
]}

Forde, Nancy R. ^{[1
]}

机构：

[1] Simon Fraser Univ, Dept Phys, Burnaby, BC V5A 1S6, Canada

来源：

JOURNAL OF OPTICS A-PURE AND APPLIED OPTICS | 2007年 / 9卷 / 08期

关键词：

optical tweezers; Brownian motion; trap modulation; variance; time-sharing tweezers;

D O I：

10.1088/1464-4258/9/8/S20

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Motivated by recent attempts to use parametric resonance to calibrate the spring constant of a Brownian particle in an optical trap, we have looked systematically at the effects of modulating laser power on the motion of the trapped particle. We predict and find experimentally an increase in the particle's position variance at low laser modulation frequencies, but we find no evidence for any resonant effects in the extremely overdamped motion of the trapped particle. Our results can serve as a guide for designing multiple traps by the 'time-sharing' method.

引用

页码：S256 / S263

页数：8

共 34 条

[1] Direct observation of base-pair stepping by RNA polymerase [J].

Abbondanzieri, EA ;

Greenleaf, WJ ;

Shaevitz, JW ;

Landick, R ;

Block, SM .

NATURE, 2005, 438 (7067) :460-465

[2]

[Anonymous], 1976, BUTTERWORTH HEINEMAN, DOI DOI 10.1016/C2009-0-25569-3

[3] Power spectrum analysis for optical tweezers [J].

Berg-Sorensen, K ;

Flyvbjerg, H .

REVIEW OF SCIENTIFIC INSTRUMENTS, 2004, 75 (03) :594-612

[4] A new method to study shape recovery of red blood cells using multiple optical trapping [J].

Bronkhorst, PJH ;

Streekstra, GJ ;

Grimbergen, J ;

Nijhof, EJ ;

Sixma, JJ ;

Brakenhoff, GJ .

BIOPHYSICAL JOURNAL, 1995, 69 (05) :1666-1673

[5] Mechanical processes in biochemistry [J].

Bustamante, C ;

Chemla, YR ;

Forde, NR ;

Izhaky, D .

ANNUAL REVIEW OF BIOCHEMISTRY, 2004, 73 :705-748

[6] Dynamic holographic optical tweezers [J].

Curtis, JE ;

Koss, BA ;

Grier, DG .

OPTICS COMMUNICATIONS, 2002, 207 (1-6) :169-175

[7] Single-molecule study of transcriptional pausing and arrest by E-coli RNA polymerase [J].

Davenport, RJ ;

Wuite, GJL ;

Landick, R ;

Bustamante, C .

SCIENCE, 2000, 287 (5462) :2497-2500

[8] Comment on "Direct measurement of the oscillation frequency in an optical-tweezers trap by parametric excitation" [J].

Deng, Yi ;

Forde, Nancy R. ;

Bechhoefer, John .

PHYSICAL REVIEW LETTERS, 2007, 98 (18)

[9]

DUFRESNE E, 2006, COMMUNICATION

[10] Using mechanical force to probe the mechanism of pausing and arrest during continuous elongation by Escherichia coli RNA polymerase [J].

Forde, NR ;

Izhaky, D ;

Woodcock, GR ;

Wuite, GJL ;

Bustamante, C .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (18) :11682-11687

← 1 2 3 4 →