Electrochemical Sensor for Enantioselective Recognition of Naproxen Using L- Cysteine/Reduced Graphene Oxide Modified Glassy Carbon Electrode

The electrochemical response of S- and R-naproxen enantiomers were investigated on L-cysteine/reduced graphene oxide modified glassy carbon electrode (L-Cys/RGO/GCE). The production of the reduced graphene oxide and L-cysteine on the surface of the glassy carbon electrode was done by using electrochemical processes. Cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used to study the enantioselective interaction between the chiral surface of the electrode and naproxen (NAP) enantiomers. The L-Cys/RGO/GCE was found to be successfully enantioselective toward sensing S-NAP in the presence of R-NAP. The linear dynamic range was found to be 5.0 x 10(-6) -1.3 x 10(-4) M for both naproxen enantiomers with detection limits of 3.5 x 10(-7) and 2.5 x 10(-6) M for S- and R-NAP, respectively.