PLGA-Based Nanoparticles in Cancer Treatment

被引：408

作者：

Rezvantalab, Sima ^{[1
,2
,3
]}

Drude, Natascha Ingrid ^{[2
,3
,4
]}

Moraveji, Mostafa Keshavarz ^{[1
]}

Guevener, Nihan ^{[2
,3
]}

Koons, Emily Kate ^{[5
,6
]}

Shi, Yang ^{[2
,3
]}

Lammers, Twan ^{[2
,3
]}

Kiessling, Fabian ^{[2
,3
]}

机构：

[1] Amirkabir Univ Technol, Tehran Polytech, Dept Chem Engn, Tehran, Iran

[2] Rhein Westfal TH Aachen, Univ Clin, Inst Expt Mol Imaging, Aachen, Germany

[3] Rhein Westfal TH Aachen, Helmholtz Inst Biomed Engn, Aachen, Germany

[4] Uniklin RWTH Aachen Univ, Dept Nucl Med, Aachen, Germany

[5] Univ Arizona, Coll Pharm, Dept Pharmacol & Toxicol, Tucson, AZ 85721 USA

[6] Univ Arizona, UA Canc Ctr, Tucson, AZ USA

来源：

FRONTIERS IN PHARMACOLOGY | 2018年 / 9卷

关键词：

PLGA; nanoparticles; drug delivery; cancer treatment; combination therapy; DOCETAXEL-LOADED PLGA; IN-VITRO; DRUG-DELIVERY; CO-DELIVERY; POLYMERIC NANOPARTICLES; PEG NANOPARTICLES; IRON-OXIDE; NANOPRECIPITATION METHOD; TARGETED NANOPARTICLES; PHOTODYNAMIC THERAPY;

D O I：

10.3389/fphar.2018.01260

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Nanomedicines can be used for a variety of cancer therapies including tumor-targeted drug delivery, hyperthermia, and photodynamic therapy. Poly (lactic-co-glycolic acid) (PLGA)-based materials are frequently used in such setups. This review article gives an overview of the properties of previously reported PLGA nanoparticles (NPs), their behavior in biological systems, and their use for cancer therapy. Strategies are emphasized to target PLGA NPs to the tumor site passively and actively. Furthermore, combination therapies are introduced that enhance the accumulation of NPs and, thereby, their therapeutic efficacy. In this context, the huge number of reports on PLGA NPs used as drug delivery systems in cancer treatment highlight the potential of PLGA NPs as drug carriers for cancer therapeutics and encourage further translational research.

引用

页数：19

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