Rhodium-Catalyzed Annulation of Primary Benzylamine with α-Diazo Ketone toward Isoquinoline

被引：46

作者：

Chu, Haoke ^{[1
]}

Xue, Peiran ^{[1
]}

Yu, Jin-Tao ^{[1
]}

Cheng, Jiang ^{[1
]}

机构：

[1] Changzhou Univ, Jiangsu Prov Key Lab Fine Petrochem Engn, Sch Petrochem Engn, Jiangsu Key Lab Adv Catalyt Mat & Technol, Changzhou 213164, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2016年 / 81卷 / 17期

基金：

中国国家自然科学基金;

关键词：

C-H ACTIVATION; BISCHLER-NAPIERALSKI REACTION; SUBSTITUTED VINYL ACETATES; PICTET-SPENGLER REACTION; INTERNAL ALKYNES; RH(III)-CATALYZED SYNTHESIS; EFFICIENT SYNTHESIS; AROMATIC KETIMINES; METHYL ARENES; DERIVATIVES;

D O I：

10.1021/acs.joc.6b01378

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Rhodium-catalyzed annulation of commercially available primary benzylamine with alpha-diazo ketone was developed, leading to isoquinolines in moderate to good yields. This procedure features the employment of primary benzylamine as starting material as well as high selectivity in the 3- and 4- position of isoquinoline, generating a key compliment to the previously developed annulation with internal alkyne.

引用

页码：8009 / 8013

页数：5

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