Second-generation antipsychotics and constipation: A review of the literature

被引：100

作者：

De Hert, M. ^{[1
]}

Hudyana, H. ^{[1
]}

Dockx, L. ^{[2
]}

Bernagie, C. ^{[2
]}

Sweers, K. ^{[1
]}

Tack, J. ^{[3
]}

Leucht, S. ^{[4
]}

Peuskens, J. ^{[1
]}

机构：

[1] Catholic Univ Louvain, Univ Psychiat Ctr, B-3070 Kortenberg, Belgium

[2] Catholic Univ Louvain, Fac Med, B-3000 Louvain, Belgium

[3] Catholic Univ Louvain, Dept Gastroenterol, B-3000 Louvain, Belgium

[4] Tech Univ Munich, Klinikum Rechts Isar, Dept Psychiat & Psychotherapy, D-81675 Munich, Germany

来源：

EUROPEAN PSYCHIATRY | 2011年 / 26卷 / 01期

关键词：

Schizophrenia; Antipsychotics; Side effects; Constipation; Physical health; BIOLOGICAL-PSYCHIATRY WFSBP; PARALYTIC ILEUS; ATYPICAL ANTIPSYCHOTICS; CHRONIC-SCHIZOPHRENIA; WORLD-FEDERATION; CLOZAPINE; OLANZAPINE; QUETIAPINE; RISPERIDONE; GUIDELINES;

D O I：

10.1016/j.eurpsy.2010.03.003

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Antipsychotics are the cornerstone in the management of psychotic disorders and schizophrenia. They are effective agents but also have a wide range of side effects. In the recent literature constipation as possible side effect has received little attention. A review of the literature concerning constipation associated with antipsychotics was performed. Overall constipation is a rarely studied or reported side effect of antipsychotic medication. Nevertheless constipation is a common side effect. Antipsychotic agents differ in their liability to induce constipation. Constipation can be severe and can lead to serious consequences such as paralytic ileus, bowel occlusion and death. Active Screening, monitoring and treatment are recommended. Further research on incidence, prevalence, underlying mechanisms and preventive measures is required. (C) 2010 Elsevier Masson SAS. All rights reserved.

引用

页码：34 / 44

页数：11

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