Therapeutic roles of mesenchymal stem cell-derived extracellular vesicles in cancer

被引：295
作者：
Weng, Zhijie [1 ]
Zhang, Bowen [2 ]
Wu, Chenzhou [1 ]
Yu, Fanyuan [3 ]
Han, Bo [2 ]
Li, Bo [4 ]
Li, Longjiang [1 ]
机构：
[1] Sichuan Univ, Natl Clin Res Ctr Oral Dis, Dept Head & Neck Oncol, State Key Lab Oral Dis,West China Hosp Stomatol, Chengdu, Peoples R China
[2] Sichuan Univ, Natl Clin Res Ctr Oral Dis, Dept Comfort Care Dent Ctr, State Key Lab Oral Dis,West China Hosp Stomatol, Chengdu, Peoples R China
[3] Sichuan Univ, State Key Lab Oral Dis, Natl Clin Res Ctr Oral Dis, West China Hosp Stomatol, Chengdu, Peoples R China
[4] Sichuan Univ, State Key Lab Oral Dis, Natl Clin Res Ctr Oral Dis, Dept Orthodont,West China Hosp Stomatol, Chengdu, Peoples R China
来源：
JOURNAL OF HEMATOLOGY & ONCOLOGY | 2021年 / 14卷 / 01期
基金：
中国国家自然科学基金; 中国博士后科学基金;
关键词：
Mesenchymal stem cell; Extracellular vesicle; Exosome; Cancer therapy; Drug delivery; DENSITY-GRADIENT SEPARATION; DRUG-DELIVERY VEHICLES; MARROW STROMAL CELLS; IN-VITRO; TARGETED-DELIVERY; ADIPOSE-TISSUE; MEDIATED DELIVERY; TUMOR-GROWTH; EXOSOMES; PROGRESSION;
D O I：
10.1186/s13045-021-01141-y
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Extracellular vesicles (EVs) are cell-derived membrane structures enclosing proteins, lipids, RNAs, metabolites, growth factors, and cytokines. EVs have emerged as essential intercellular communication regulators in multiple physiological and pathological processes. Previous studies revealed that mesenchymal stem cells (MSCs) could either support or suppress tumor progression in different cancers by paracrine signaling via MSC-derived EVs. Evidence suggested that MSC-derived EVs could mimic their parental cells, possessing pro-tumor and anti-tumor effects, and inherent tumor tropism. Therefore, MSC-derived EVs can be a cell-free cancer treatment alternative. This review discusses different insights regarding MSC-derived EVs' roles in cancer treatment and summarizes bioengineered MSC-derived EVs' applications as safe and versatile anti-tumor agent delivery platforms. Meanwhile, current hurdles of moving MSC-derived EVs from bench to bedside are also discussed.
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页数：22
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