miR-146a promoted breast cancer proliferation and invasion by regulating NM23-H1

被引：25

作者：

Chen, Jun ^{[1
]}

Jiang, Qiang ^{[2
]}

Jiang, Xue-Qin ^{[1
]}

Li, De-Quan ^{[1
]}

Jiang, Xiao-Cheng ^{[1
]}

Wu, Xiao-Bo ^{[1
]}

Cao, Ya-Li ^{[1
]}

机构：

[1] 3rd Hosp Nanchang, Breast Tumor Dept, 2 Xiangshan South Rd, Nanchang 330009, Jiangxi, Peoples R China

[2] Jiangxi Prov Chest Hosp, Oncol Dept, 346 Dieshan Rd, Nanchang 330100, Jiangxi, Peoples R China

来源：

JOURNAL OF BIOCHEMISTRY | 2020年 / 167卷 / 01期

关键词：

breast cancer; Hsa-miR-146a; invasion; NM23-H1; proliferation; METASTASIS SUPPRESSOR; MICRORNAS; DIFFERENTIATION; EXPRESSION; INTERACTS; CELLS; GENE;

D O I：

10.1093/jb/mvz079

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The study aimed to investigate the regulatory effect of miR-146a in proliferation, invasion and migration of breast cancer and its possible mechanism via NM23-H1. The expression levels of miR-146a in breast cancer with different pathological classification were significantly increased, while the expression levels of NM23-H1 were significantly decreased, which were closely correlated. Double luciferase reporter gene was used to verify the target regulatory relationship between miR-146 and NM23-H1 on a human breast cancer cell line. miR-146a was closely related to the proliferation and metastasis of breast cancer. miR-146a also promoted the growth of breast cancer in vivo via targeting NM23-H1. In conclusion, miR-146 can promote the proliferation and invasion of breast cancer by targeting NM23-H1.

引用

页码：41 / 48

页数：8

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