Asymmetric construction of benzylic quaternary carbons from chiral malonates: Formal synthesis of both (-)- and (+)-aminoglutethimides AG and analogues

被引：33

作者：

Fadel, A

GarciaArgote, S

机构：

[1] Laboratoire des Carbocycles, Inst. de Chimie Moleculaire d'Orsay, Universite de Paris-Sud

来源：

TETRAHEDRON-ASYMMETRY | 1996年 / 7卷 / 04期

关键词：

D O I：

10.1016/0957-4166(96)00122-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

From a single chiron (R)-(+)-5, available with high enantiomeric excess (97%) by enzymatic hydrolysis (PLE acetonic powder) of a malonate, were prepared convenient precursors of aminoglutethimides (-)-AG-1 and (+)-AG-1. This versatile method also allows preparation of the b-hydroxy ester (R)-9 and its enantiomer (S)-9 as well as the glutethimides (S)-4 and (R)-4 and other analogues. Copyright (C) 1996 Elsevier Science Ltd

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页码：1159 / 1166

页数：8

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