Evaluating real-world COVID-19 vaccine effectiveness using a test-negative case-control design

被引：7

作者：

Reynolds, Matthew W. ^{[1
]}

Secora, Alex ^{[1
]}

Joules, Alice ^{[1
]}

Albert, Lisa ^{[1
]}

Brinkley, Emma ^{[1
]}

Kwon, Tom ^{[1
]}

Mack, Christina ^{[1
]}

Toovey, Stephen ^{[2
]}

Dreyer, Nancy A. ^{[1
]}

机构：

[1] IQVIA Real World Solutions, 201 Broadway, Cambridge, MA 02139 USA

[2] Pegasus Res, Neuschwaendistr 6, CH-6390 Engelberg, Switzerland

来源：

JOURNAL OF COMPARATIVE EFFECTIVENESS RESEARCH | 2022年 / 11卷 / 16期

关键词：

COVID-19; patient-reported outcomes; person-generated health data; SARS-CoV-2; symptoms; test-negative design; vaccines; PREVENTING SARS-COV-2 INFECTION; 8 US LOCATIONS; FRONTLINE WORKERS; PEOPLE;

D O I：

10.2217/cer-2022-0069

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Aim: It is important to assess if clinical trial efficacy translates into real-world effectiveness for COVID-19 vaccines. Materials & methods: We conducted a modified test-negative design (TND) to evaluate the real-world effectiveness of three COVID-19 vaccines. We defined cases in two ways: self-reported COVID-19-positive tests, and self-reported positive tests with >= 1 moderate/severe COVID-19 symptom. Results: Any vaccination was associated with a 95% reduction in subsequently reporting a positive COVID-19 test, and a 71% reduction in reporting a positive test and >= 1 moderate/severe symptom. Conclusion: We observed high effectiveness across all three marketed vaccines, both for self-reported positive COVID-19 tests and moderate/severe COVID-19 symptoms. This innovative TND approach can be implemented in future COVID-19 vaccine and treatment real-world effectiveness studies. Clinicaltrials.gov identifier: .

引用

页码：1161 / 1172

页数：12

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