Two New Phenylhydrazone Derivatives from the Pearl River Estuary Sediment-Derived Streptomyces sp. SCSIO 40020

被引：7
|
作者：
Liu, Wei [1 ,2 ]
Ma, Liang [1 ,3 ]
Zhang, Liping [1 ,3 ]
Chen, Yuchan [2 ]
Zhang, Qingbo [1 ,3 ]
Zhang, Haibo [1 ,3 ]
Zhang, Weimin [2 ]
Zhang, Changsheng [1 ,3 ,4 ]
Zhang, Wenjun [1 ,3 ,4 ]
机构：
[1] Chinese Acad Sci, Innovat Acad South China Sea Ecol & Environm Engn, South China Sea Inst Oceanol, Key Lab Trop Marine Bioresources & Ecol,Guangdong, 164 West Xingang Rd, Guangzhou 510301, Peoples R China
[2] Guangdong Acad Sci, Inst Microbiol, State Key Lab Appl Microbiol Southern China, 100 Cent Xianlie Rd, Guangzhou 510070, Peoples R China
[3] Southern Marine Sci & Engn Guangdong Lab Guangzho, 1119 Haibin Rd, Guangzhou 511458, Peoples R China
[4] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
MARINE DRUGS | 2022年 / 20卷 / 07期
关键词：
penzonemycins; phenylhydrazones; Streptomyces sp; Japp-Klingemann coupling reaction; marine natural products; NATURAL-PRODUCTS; BIOSYNTHESIS;
D O I：
10.3390/md20070449
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Two new phenylhydrazone derivatives and one new alkaloid, penzonemycins A-B (1-2) and demethylmycemycin A (3), together with three known compounds including an alkaloid (4) and two sesquiterpenoids (5-6), were isolated from the Streptomyces sp. SCSIO 40020 obtained from the Pearl River Estuary sediment. Their structures and absolute configurations were assigned by 1D/2D NMR, mass spectroscopy and X-ray crystallography. Compound 1 was evaluated in four human cancer cell lines by the SRB method and displayed weak cytotoxicity in three cancer cell lines, with IC50 values that ranged from 30.44 to 61.92 mu M, which were comparable to those of the positive control cisplatin. Bioinformatic analysis of the putative biosynthetic gene cluster indicated a Japp-Klingemann coupling reaction involved in the hydrazone formation of 1 and 2.
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页数：12
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