Cross-talk between SIRT1 and endocrine factors: effects on energy homeostasis

被引：25

作者：

Quinones, Mar ^{[1
,2
]}

Al-Massadi, Omar ^{[1
,2
]}

Ferno, Johan ^{[3
]}

Nogueiras, Ruben ^{[1
,2
]}

机构：

[1] Univ Santiago de Compostela, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Sch Med CIMUS, Dept Physiol,Inst Invest Sanitaria IDIS, Santiago De Compostela 15782, A Coruna, Spain

[2] Univ Santiago de Compostela, CIBER Fisiopatol Obesidad & Nutr CIBERobn, Sch Med CIMUS, Dept Physiol,Inst Invest Sanitaria IDIS, Santiago De Compostela 15782, Spain

[3] Univ Bergen, KG Jebsen Ctr Diabet Res, Dept Clin Sci, Bergen, Norway

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 2014年 / 397卷 / 1-2期

关键词：

Food intake; Hormones; Insulin; Obesity; SIRT1; FATTY-ACID-METABOLISM; REGULATES INSULIN-SECRETION; PANCREATIC BETA-CELLS; HEPATIC GLUCONEOGENIC GENES; TRANSCRIPTION FACTOR FKHR; EXTENDS LIFE-SPAN; CALORIE RESTRICTION; THYROID-HORMONE; ADIPOSE-TISSUE; UNCOUPLING PROTEIN-2;

D O I：

10.1016/j.mce.2014.08.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mammalian sirtuins (SIRT1-7) are a family of highly conserved nicotine adenine dinucleotide (NAD(+))-dependent deacetylases that act as cellular sensors to detect energy availability. SIRT1 is a multifaceted protein that is involved in a wide variety of cellular processes. SIRT1 is activated in response to caloric restriction, acting on multiple targets in a wide range of tissues. SIRT1 regulates the role of multiple hormones implicated in energy balance, including glucose and lipid metabolism. Here, we review the relevant role of SIRT1 as a mediator of endocrine function of several hormones to modulate energy balance. In addition, we analyze the potential of targeting SIRT1 for the treatment of obesity and type 2 diabetes mellitus. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：42 / 50

页数：9

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